| Type: | Family | Name: | SUMO-activating enzyme subunit SAE2/Uba2 |
| Description: | The SUMO activating enzyme E1 enzyme facilitates conjugation of ubiquitin and ubiquitin-like proteins through adenylation, thioester transfer within E1, and thioester transfer from E1 to E2 conjugating proteins []. This entry represents a subunit of the E1 enzyme, including Uba2 from yeasts [] and SAE2 from animals []. E1 enzymes mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 [, ]. | Short Name: | SAE2/Uba2 |
