| Type: | Family | Name: | Protein phosphatase 2A regulatory subunit PR55 |
| Description: | Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase implicated in many cellular processes, including the regulation of metabolic enzymes and proteins involved in signal transduction [, ]. PP2A is a trimercomposed of a 36 kDa catalytic subunit, a 65 kDa regulatory subunit (subunit A) and a variable third subunit (subunit B) [, ]. Subunits B can be classified into three subfamilies, the R2/B/PR55/B55, the R3/B''/PR72/PR130/PR59 and the R5/B'/B56 families. This entry represent the R2/B/PR55/B55 family, which exists in Drosophila melanogaster and yeast, and has up to three isoforms in mammals (alpha/beta/gamma) [, ]. PR55 may act as a substrate recognition unit, or may help to target the enzyme to thecorrect subcellular location []. In budding yeasts, it is also known as Cdc55, which is essential for the spindle assembly checkpoint (SAC) []. In flies, it is also known as PP2A-twins, which collaborates with polo kinase for cell cycle progression and centrosome attachment to nuclei in Drosophila embryos []. | Short Name: | PP2A_PR55 |
