Type: | Domain | Name: | Intimal thickness related receptor, IRP |
Description: | This entry represents a novel protein with seven transmembrane alpha-helical domains, termed it ITR (intimal thickness-related receptor). The ITR sequence contains a motif common to the Rhodopsin-like GPCR (G protein-coupled receptor) superfamily. In vivo analyses of this gene revealed that expression of ITR protein increased with intimal thickening induced by cuff placement around murine femoral artery. Furthermore, ITR-knockout mice were found to be resistant to this experimental intimal thickening []. | Short Name: | Intimal_thickness-rel_rcpt |