| Type: | Domain | Name: | VHS subgroup |
| Description: | The VHS domain is a ~140 residues long domain, whose name is derived from its occurrence in VPS-27, Hrs and STAM. Based on regions surrounding the domain, VHS-proteins can be divided into 4 groups []: STAM/EAST/Hbp which all share the domain composition VHS-SH3-ITAM and carry one or two ubiquitin-interacting motifsProteins with a FYVE domain () C-terminal to VHS which also carry one or two ubiquitin-interacting motifsGGA proteins with a domain composition VHS-GAT (GGA and Tom1) homology domainVHS domain alone or in combination with domains other than those listed aboveThe VHS domain is always found at the N- terminus of proteins suggesting that such topology is important for function. The domain is considered to have a general membrane targeting/cargo recognition role in vesicular trafficking [].Resolution of the crystal structure of the VHS domain of Drosophila Hrs and human Tom1 revealed that it consists of eight helices arranged in a double-layer superhelix []. The existence of conserved patches of residues on the domain surface suggests that VHS domains may be involved in protein-protein recognition and docking. Overall, sequence similarity is low (approx 25%) amongst domain family members. In this entry, the domain is found in ADP-ribosylation factor-binding proteins and Hepatocyte growth factor-regulated tyrosine kinase substrates as well as vacuolar protein-sorting machinery proteins, amongst others. | Short Name: | VHS_subgr |
