Protein Domain : IPR004000

Type:  Family Name:  Actin family
Description:  Actin [, ] is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. These filaments interact with myosin to produce a sliding effect, which is the basis of muscular contraction and many aspects of cell motility, including cytokinesis. Each actin protomer binds one molecule of ATP and has one high affinity site for either calcium or magnesium ions, as well as several low affinity sites. Actin exists as a monomer in low salt concentrations, but filaments form rapidly as salt concentration rises, with the consequent hydrolysis of ATP. Actin from many sources forms a tight complex with deoxyribonuclease (DNase I) although the significance of this is still unknown. The formation of this complex results in the inhibition of DNase I activity, and actin loses its ability to polymerise. It has been shown that an ATPase domain of actin shares similarity with ATPase domains of hexokinase and hsp70proteins [, ].In vertebrates there are three groups of actin isoforms: alpha, beta and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exists in most cell types as components of the cytoskeleton and as mediators of internal cell motility. In plants there are many isoforms which are probably involved in a variety of functions such as cytoplasmic streaming, cell shape determination, tip growth, graviperception, cell wall deposition, etc.Recently some divergent actin-like proteins have been identified in several species. These proteins include centractin (actin-RPV) from mammals, fungi yeast ACT5, Neurospora crassaro-4) and Pneumocystis carinii, which seems to be a component of a multi-subunit centrosomal complex involved in microtubule based vesicle motility (this subfamily is known as ARP1); ARP2 subfamily, which includes chicken ACTL, Saccharomyces cerevisiaeACT2, Drosophila melanogaster14D and Caenorhabditis elegansactC; ARP3 subfamily, which includes actin 2 from mammals, Drosophila 66B, yeast ACT4 and Schizosaccharomyces pombeact2; and ARP4 subfamily, which includes yeast ACT3 and Drosophila 13E. Short Name:  Actin
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19 Child Features

DB identifier Type Name
IPR015623 Family Actin-related protein 3
IPR027667 Family Actin-related protein 4
IPR030071 Family Plant actin-related protein 8
IPR027664 Family Actin-related protein 5
IPR027668 Family Actin-related protein 8/Plant actin-related protein 9
IPR027306 Family Actin-related protein 2
IPR029909 Family Actin-related protein 1 family
IPR027678 Family Actin-related protein 7, plant
IPR030054 Family Actin-related protein 6
IPR029911 Family Actin-related protein 7, fungi
IPR029912 Family Actin-like protein 6A
IPR030068 Family Actin-related protein T3
IPR030074 Family Actin-like protein 9
IPR030139 Family Actin-related protein T1
IPR027127 Family Actin-related protein 10
IPR027665 Family Actin-related protein 9, fungi
IPR027666 Family Actin-related protein T2
IPR027679 Family Actin-like protein 7A
IPR027680 Family Actin-like protein 7B

2 Contains

DB identifier Type Name
IPR004001 Conserved_site Actin, conserved site
IPR020902 Conserved_site Actin/actin-like conserved site

4 Cross Referencess

Identifier
PTHR11937
PF00022
PR00190
SM00268

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
230187 D8QXQ2 PAC:15411678 Selaginella moellendorffii 376  
80115 D8QWL0 PAC:15402935 Selaginella moellendorffii 370  
175848 D8S0E5 PAC:15401333 Selaginella moellendorffii 389  
178381 D8S0X0 PAC:15406373 Selaginella moellendorffii 377  
420505 D8SC75 PAC:15413607 Selaginella moellendorffii 429  
233752 D8SDU1 PAC:15402538 Selaginella moellendorffii 376  
180402 D8SK21 PAC:15413190 Selaginella moellendorffii 420  
266988 D8R5L0 PAC:15412264 Selaginella moellendorffii 415  
89667 D8RAR0 PAC:15411000 Selaginella moellendorffii 469  
410245 D8RE43 PAC:15404062 Selaginella moellendorffii 600  
131582 D8T4D3 PAC:15403258 Selaginella moellendorffii 711  
evm.model.supercontig_1.401 PAC:16404346 Carica papaya 366  
evm.model.supercontig_1.425 PAC:16404372 Carica papaya 420  
evm.model.supercontig_1.426 PAC:16404373 Carica papaya 288  
evm.model.supercontig_114.30 PAC:16406121 Carica papaya 350  
evm.model.supercontig_12.72 PAC:16406914 Carica papaya 462  
evm.model.supercontig_13.24 PAC:16407758 Carica papaya 465  
evm.model.supercontig_2.45 PAC:16412832 Carica papaya 377  
evm.model.supercontig_33.85 PAC:16417732 Carica papaya 427  
evm.model.supercontig_360.2 PAC:16418491 Carica papaya 406  
evm.model.supercontig_42.93 PAC:16419858 Carica papaya 198  
evm.model.supercontig_44.85 PAC:16420228 Carica papaya 205  
evm.model.supercontig_46.24 PAC:16420488 Carica papaya 422  
evm.model.supercontig_81.167 PAC:16426927 Carica papaya 377  
evm.model.supercontig_81.159 PAC:16426918 Carica papaya 377  
evm.model.supercontig_85.64 PAC:16427501 Carica papaya 611  
29739.m003732 B9RR79 PAC:16807510 Ricinus communis 376  
29836.m000559 PAC:16810272 Ricinus communis 377  
29864.m001496 B9RVQ0 PAC:16811806 Ricinus communis 360  
29927.m000609 B9SMG5 PAC:16813718 Ricinus communis 449  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1388079
            8448030
            1828889
            1323828