Protein Domain : IPR017981

Type:  Domain Name:  GPCR, family 2-like
Description:  G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].The secretin-like GPCRs include secretin [], calcitonin [], parathyroid hormone/parathyroid hormone-related peptides [] and vasoactive intestinal peptide [], all of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. These receptors contain seven transmembrane regions, in a manner reminiscent of the rhodopsins and other receptors believed to interact with G-proteins (however there is no significant sequence identity between these families, the secretin-like receptors thus bear their own unique '7TM' signature). Their N terminus is probably located on the extracellular side of the membrane and potentially glycosylated. This N-terminal region contains a long conserved region which allow the binding of large peptidic ligand such as glucagon, secretin, VIP and PACAP; this region contains five conserved cysteines residues which could be involved in disulphide bond. The C-terminal region of these receptor is probably cytoplasmic. Every receptor gene in this family is encoded on multiple exons, and several of these genes are alternatively spliced to yield functionally distinct products. This entry represents the family 2 GPCR receptor proteins and Frizzled proteins. Short Name:  GPCR_2-like
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1 Child Features

DB identifier Type Name
IPR000848 Domain GPCR, cAMP-type

0 Contains

1 Cross References

Identifier
PS50261

20 Found Ins

DB identifier Type Name
IPR022343 Family GCR1-cAMP receptor
IPR022340 Family G protein-coupled receptor GCR1 putative
IPR002001 Family GPCR, family 2, diuretic hormone receptor
IPR002284 Family GPCR, family 2, vasoactive intestinal peptide receptor 2
IPR001571 Family GPCR, family 2, vasoactive intestinal peptide receptor
IPR002285 Family GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor
IPR015526 Family Frizzled/secreted frizzled-related protein
IPR003056 Family GPCR, family 2, CD97 antigen
IPR015630 Family Latrophilin-3
IPR003924 Family GPCR, family 2, latrophilin
IPR003051 Family GPCR, family 2, corticotropin releasing factor receptor
IPR003287 Family GPCR, family 2, calcitonin receptor family
IPR003053 Family GPCR, family 2, corticotropin releasing factor receptor, type 2
IPR001688 Family GPCR, family 2, calcitonin receptor
IPR003289 Family GPCR, family 2, calcitonin gene-related peptide, type 1 receptor
IPR003288 Family GPCR, family 2, growth hormone-releasing hormone receptor
IPR003290 Family GPCR, family 2, glucagon-like peptide-1/glucagon receptor
IPR003291 Family GPCR, family 2, glucagon receptor
IPR003292 Family GPCR, family 2, glucagon-like peptide-1 receptor
IPR001771 Family GPCR, family 2, vasoactive intestinal peptide receptor 1

3 GO Annotations

GO Term Gene Name
GO:0004888 IPR017981
GO:0007166 IPR017981
GO:0016020 IPR017981

3 Ontology Annotations

GO Term Gene Name
GO:0004888 IPR017981
GO:0007166 IPR017981
GO:0016020 IPR017981

0 Parent Features

439 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
89633 D8RBE4 PAC:15410918 Selaginella moellendorffii 263  
evm.model.supercontig_146.16 PAC:16409103 Carica papaya 320  
29889.m003405 B9S014 PAC:16812351 Ricinus communis 319  
Cucsa.271130.1 A0A0A0L5G2 PAC:16973486 Cucumis sativus 318  
orange1.1g021325m A0A067G9S2 PAC:18109689 Citrus sinensis 314  
orange1.1g023732m A0A067FY27 PAC:18109690 Citrus sinensis 278  
AT1G48270.1 O04714 PAC:19654618 Arabidopsis thaliana 326  
Thhalv10011644m V4KLB6 PAC:20184400 Eutrema salsugineum 328  
Ciclev10005468m V4RF20 PAC:20791832 Citrus clementina 314  
Lus10018333 PAC:23179362 Linum usitatissimum 325  
Lus10017120 PAC:23167457 Linum usitatissimum 529  
Potri.008G206000.2 B9HMQ6 PAC:27036087 Populus trichocarpa 315  
Potri.008G206000.1 PAC:27036086 Populus trichocarpa 341  
Potri.008G206000.3 PAC:27036088 Populus trichocarpa 281  
Gorai.005G073100.1 A0A0D2RAL6 PAC:26804912 Gossypium raimondii 313  
Gorai.005G073100.2 A0A0D2SC82 PAC:26804911 Gossypium raimondii 313  
Thecc1EG021504t2 A0A061EQI4 PAC:27454744 Theobroma cacao 313  
Thecc1EG021504t1 A0A061ERC5 PAC:27454743 Theobroma cacao 313  
Migut.E01785.1.p A0A022QUG9 PAC:28920900 Mimulus guttatus 321  
Araha.3325s0001.1.p PAC:28839199 Arabidopsis halleri 319  
Cagra.6122s0002.1.p PAC:28893805 Capsella grandiflora 326  
Glyma.14G107200.1.p A0A0R0GBN8 PAC:30532327 Glycine max 318  
Glyma.14G107200.2.p A0A0R0GBI7 PAC:30532328 Glycine max 297  
Glyma.14G107200.3.p A0A0R0GBQ3 PAC:30532329 Glycine max 284  
Glyma.17G219300.1.p I1MX10 PAC:30480969 Glycine max 318  
Brara.F00440.1.p A0A397YYW3 PAC:30628673 Brassica rapa FPsc 329  
Bostr.15654s0005.1.p PAC:30680367 Boechera stricta 326  
Medtr1g015010.1 G7I8Y3 PAC:31092464 Medicago truncatula 308  
SapurV1A.0144s0210.1.p PAC:31416587 Salix purpurea 316  
Spipo0G0029700 PAC:31508137 Spirodela polyrhiza 315  

11 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8170923
            16753280
            23020293
            12679517
            8081729
            15914470
            18948278
            1646711
            1314625
            1658940
            1658941