| Type: | Domain | Name: | Hypoxia induced protein, domain |
| Description: | The hypoxia induced gene 1 (HIG1) or hypoglycemia/hypoxia inducible mitochondrial protein (HIMP1) is up-regulated by stresses of themicroenvironment such as low oxygen or low glucose conditions. HIG1 is a mitochondrial inner membrane protein, which is ubiquitously expressed. It ispredicted to be an integral membrane protein consisting of two hydrophobic helices, 21-23 residues in length that might tend to form a hairpin-like loopacross the bilayer. HIG1 could be implied in apoptotic or cytoprotective signals. HIG1 is a member of a well conserved eukaryote protein family. Thepredicted transmembrane helice (TMH) and loop regions represent the most highly conserved regions in these proteins [, ].The profile we developed covers the predicted TMH and loop regions.This domain is found in proteins thought to be involved in the response to hypoxia []. It is also found in altered inheritance of mitochondria proteins. | Short Name: | Hypoxia_induced_domain |
