Protein Domain : IPR024072

Type:  Domain Name:  Dihydrofolate reductase-like domain
Description:  Dihydrofolate reductase (DHFR) catalyses the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, an essential step in de novosynthesis both of glycine and of purines and deoxythymidine phosphate (the precursors of DNA synthesis) [], and important also in the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate.This entry represents a structural domain found in dihydrofolate reductases, as well as in riboflavin biosynthesis proteins (usually as a C-terminal domain) and related enzymes. Short Name:  DHFR-like_dom
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2 Child Features

DB identifier Type Name
IPR001796 Domain Dihydrofolate reductase domain
IPR002734 Domain Bacterial bifunctional deaminase-reductase, C-terminal

0 Contains

2 Cross Referencess

Identifier
G3DSA:3.40.430.10
SSF53597

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
404548 D8QVP4 PAC:15411015 Selaginella moellendorffii 502  
413571 D8RQP7 PAC:15415363 Selaginella moellendorffii 144  
413953 D8RR58 PAC:15418327 Selaginella moellendorffii 311  
102410 D8RVG7 PAC:15406005 Selaginella moellendorffii 563  
417567 D8S2W0 PAC:15404522 Selaginella moellendorffii 145  
169709 D8RAR1 PAC:15404923 Selaginella moellendorffii 375  
evm.TU.contig_27491.2 PAC:16429499 Carica papaya 429  
evm.model.supercontig_238.3 PAC:16414440 Carica papaya 122  
evm.model.supercontig_2508.1 PAC:16414919 Carica papaya 342  
evm.model.supercontig_39.15 PAC:16419022 Carica papaya 257  
evm.model.supercontig_53.118 PAC:16422179 Carica papaya 346  
evm.model.supercontig_73.17 PAC:16425593 Carica papaya 152  
29929.m004573 B9RM69 PAC:16813813 Ricinus communis 600  
30131.m007071 B9RH79 PAC:16818896 Ricinus communis 528  
30170.m014082 B9R7Y4 PAC:16821918 Ricinus communis 591  
35073.m000031 B9TJV2 PAC:16826474 Ricinus communis 176  
28946.m000033 B9TB69 PAC:16802014 Ricinus communis 215  
Cucsa.109460.1 PAC:16959861 Cucumis sativus 558  
Cucsa.109460.2 A0A0A0LPA5 PAC:16959862 Cucumis sativus 527  
Cucsa.109460.9 A0A0A0LPA5 PAC:16959869 Cucumis sativus 527  
Cucsa.135470.1 A0A0A0KCZ2 PAC:16962934 Cucumis sativus 425  
Cucsa.356660.2 PAC:16980334 Cucumis sativus 467  
Cucsa.356660.1 A0A0A0M0K4 PAC:16980333 Cucumis sativus 605  
Cucsa.356640.1 PAC:16980329 Cucumis sativus 327  
Cucsa.258950.1 A0A0A0L603 PAC:16972938 Cucumis sativus 164  
orange1.1g009737m A0A067E213 PAC:18113578 Citrus sinensis 527  
orange1.1g010303m A0A067DYI6 PAC:18113580 Citrus sinensis 513  
orange1.1g009746m A0A067EAF5 PAC:18113579 Citrus sinensis 527  
orange1.1g010811m A0A067DY43 PAC:18113581 Citrus sinensis 500  
orange1.1g009747m A0A067EAF5 PAC:18113577 Citrus sinensis 527  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2830673