3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0004843 | IPR001578 |
| GO:0006511 | IPR001578 |
| GO:0005622 | IPR001578 |
| Type: | Domain | Name: | Peptidase C12, ubiquitin carboxyl-terminal hydrolase |
| Description: | This group of cysteine peptidases belong to the MEROPS peptidase family C12 (ubiquitin C-terminal hydrolase family, clan CA). Families within the CA clan are loosely termed papain-like as protein fold of the peptidase unit resembles that of papain, the type example for clan CA. The type example is the human ubiquitin C-terminal hydrolase UCH-L1.Ubiquitin is highly conserved, commonly found conjugated to proteins in eukaryotic cells, where it may act as a marker for rapid degradation, orit may have a chaperone function in protein assembly []. The ubiquitin is released by cleavage from the bound protein by a protease []. A number ofdeubiquitinising proteases are known: all are activated by thiol compounds [, ], and inhibited by thiol-blocking agents and ubiquitin aldehyde [, ], and as such have the properties of cysteine proteases [].The deubiquitinsing proteases can be split into 2 size ranges (20-30 kDa and 100-200 kDa, ) []: this group are the 20-30 kDa peptides which includes the yeast yuh1. Yeast yuh1 protease is known to be active only against small ubiquitin conjugates, being inactive against conjugated beta-galactosidase []. A mammalian homologue, UCH (ubiquitin conjugate hydrolase), is one of the most abundant proteins in the brain []. Only one conserved cysteine can beidentified, along with two conserved histidines. The spacing between the cysteine and the second histidine is thought to be more representative ofthe cysteine/histidine spacing of a cysteine protease catalytic dyad []. | Short Name: | Peptidase_C12_UCH |
| GO Term | Gene Name |
|---|---|
| GO:0004843 | IPR001578 |
| GO:0006511 | IPR001578 |
| GO:0005622 | IPR001578 |
