| Type: | Family | Name: | RINT-1/TIP-20 |
| Description: | This entry includes PINT-1 from animals, Tip20 from yeasts and MAIGO2 (Mag2) from plants. They play a role in anterograde transport from the endoplasmic reticulum (ER) to the Golgi and/or retrograde transport from the Golgi to the ER share sequence similarity. They share a similar domain organisation with an N-terminal leucine heptad repeat rich coiled coil and an ~500-residue C-terminal RINT1/TIP20 domain, which might be a protein-protein interaction module necessary for the formation of functional complexes. RINT-1 interacts with Rad50 only during late S and G2/M phases and participates in radiation induced checkpoint control []. RINT1 also functions in membrane trafficking from the endoplasmic reticulum(ER) to the Golgi complex in interphase cells [, , ].TIP-20 is involved in the retrograde transport from the Golgi to the ER [, ].Arabidopsis Mag2 functions in the transport of storage protein precursors between the ER and Golgi complex in plants []. | Short Name: | RINT1_TIP20 |
