| Type: | Domain | Name: | Cyanovirin-N |
| Description: | Cyanovirin-N (CV-N) is an 11kDa protein from the cyanobacterium Nostoc ellipsosporumthat displays virucidal activity against several viruses, including human immunodeficiency virus (AIDS). The virucidal activity of CV-N is mediated through specific high-affinity interactions with the viral surface envelope glycoproteins gp120 and gp41, as well as to high-mannose oligosaccharides found on the HIV envelope []. In addition, CV-N is active against rhinoviruses, human parainfluenza virus, respiratory syncytial virus, and enteric viruses. The virucidal activity of CV-N against influenza virus is directed towards viral haemagglutinin [].The CV-N domain is evolutionarily conserved and occurs as a protein module in eukaryotes []. CV-N has a complex fold composed of a duplication of a tandem repeat of two homologous motifs comprising three-stranded beta-sheet and beta-hairpins []. | Short Name: | Cyanovirin-N |
