| Type: | Family | Name: | Defective-in-cullin neddylation protein |
| Description: | The eukaryotic defective in cullin neddylation (DCN) protein family, may contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. These multi-protein complexes are required for polyubiquitination and subsequent degradation of target proteins by the 26S proteasome []. Proteins in the DCN family include:Yeast DCN1.Vertebrate DCN1-like protein 1.Vertebrate DCN1-like protein 2.Vertebrate DCN1-like protein 4.DCN family proteins all contain a domain which is of unknown function but appears to contain the features of a basic helix-loop-helix leucine zipper (bHLH-ZIP) domain [].The N-terminal region of the protein often contains a UBA-like domain. | Short Name: | DCN-prot |
