Protein Domain : IPR002523

Type:  Family Name:  Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB
Description:  This entry includes prokaryotic magnesium transport protein CorA and its related protein, zinc transport protein ZntB []. This entry also includes eukaryotic magnesium transporters, such as mitochondrial inner membrane magnesium transporter Mrs2 and magnesium transporter Alr1 and Alr2. These proteins are characterised by the conserved GMN motif at the end of the first of twoconserved transmembrane (TM) domains near the C terminus []. Thermotoga maritima CorA (TmCorA) has been reported to be an efflux system. It only has 2 TM domains,TM1 and TM2 [, , ]. The loop connecting TM1 and TM2 contains the conserved CorA signature motifs YGMNF and MPEL. With its N- and C-terminal ends face the cytosol and its similarity to the class II CorA (a CorA group lacking the MPEL motif and may transport divalent cations out of the cell), TmCorA is predicted to be primarily involved in ion efflux []. It forms a pentameric membrane protein channel featuring a possible ion discriminating aspartate ring at the cytoplasmic entrance of the pore and two distinct cytoplasmic metal binding sites per monomer, which could have regulatory roles [, ]. It has been suggested that eukaryotic CorA homologues have the same topology and overall structure as T. maritima CorA []. In budding yeasts, Mrs2 is an essential component of the major electrophoretic Mg2+ influx system in mitochondria []. Overexpression of Alr1 or Alr2 increases tolerance to Al3+ and Ga3+ ions []. Despite generally low sequence similarity, both human Mrs2 (also known as LPE10) and S. typhimurium CorA can restore Mg2+ uptake activity in Saccharomyces cerevisiae with inactive Mrs2 []. Short Name:  MgTranspt_CorA/ZnTranspt_ZntB
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2 Child Features

DB identifier Type Name
IPR004488 Family Magnesium/cobalt transport protein CorA
IPR023714 Family Zinc transport protein ZntB

0 Contains

1 Cross References

Identifier
PF01544

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0046873 IPR002523
GO:0030001 IPR002523
GO:0055085 IPR002523
GO:0016020 IPR002523

4 Ontology Annotations

GO Term Gene Name
GO:0046873 IPR002523
GO:0030001 IPR002523
GO:0055085 IPR002523
GO:0016020 IPR002523

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
53758 D8S0E6 PAC:15417187 Selaginella moellendorffii 442  
165091 D8QSN2 PAC:15410536 Selaginella moellendorffii 406  
91491 D8REM8 PAC:15415659 Selaginella moellendorffii 387  
evm.model.supercontig_1.127 PAC:16404041 Carica papaya 419  
evm.model.supercontig_10.64 PAC:16404681 Carica papaya 443  
evm.model.supercontig_17.128 PAC:16410620 Carica papaya 550  
evm.model.supercontig_20.38 PAC:16413062 Carica papaya 263  
evm.model.supercontig_20.35 PAC:16413059 Carica papaya 324  
evm.model.supercontig_47.33 PAC:16420636 Carica papaya 291  
29693.m002068 B9S172 PAC:16806038 Ricinus communis 570  
29804.m001532 B9RX58 PAC:16809148 Ricinus communis 423  
29844.m003172 B9RTF2 PAC:16810880 Ricinus communis 398  
30131.m006875 B9RGM7 PAC:16818702 Ricinus communis 447  
41136.m000013 B9TQP0 PAC:16827378 Ricinus communis 190  
28725.m000310 B9SXF0 PAC:16801596 Ricinus communis 453  
Cucsa.331930.6 PAC:16978251 Cucumis sativus 456  
Cucsa.331930.1 PAC:16978246 Cucumis sativus 467  
Cucsa.331930.2 PAC:16978247 Cucumis sativus 456  
Cucsa.331930.3 PAC:16978248 Cucumis sativus 456  
Cucsa.331930.4 PAC:16978249 Cucumis sativus 456  
Cucsa.386610.1 A0A0A0LNR4 PAC:16982708 Cucumis sativus 393  
Cucsa.386610.2 PAC:16982709 Cucumis sativus 378  
Cucsa.177310.1 A0A0A0L9Z2 PAC:16967003 Cucumis sativus 447  
Cucsa.016360.2 PAC:16951654 Cucumis sativus 390  
Cucsa.016360.1 A0A0A0LLQ5 PAC:16951653 Cucumis sativus 397  
Cucsa.032900.1 PAC:16952502 Cucumis sativus 443  
Cucsa.212470.1 A0A0A0LX35 PAC:16969345 Cucumis sativus 547  
orange1.1g019594m PAC:18112994 Citrus sinensis 338  
orange1.1g008601m PAC:18112990 Citrus sinensis 560  
orange1.1g045110m A0A067FMC8 PAC:18093257 Citrus sinensis 376  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16857941
            12142406
            23425532
            12206392
            17619822
            9430719
            12628916