3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0006886 | IPR006896 |
| GO:0006888 | IPR006896 |
| GO:0030127 | IPR006896 |
| Type: | Domain | Name: | Sec23/Sec24, trunk domain |
| Description: | COPII (coat protein complex II)-coated vesicles carry proteins from the endoplasmic reticulum (ER) to the Golgi complex []. COPII-coated vesicles form on the ER by the stepwise recruitment of three cytosolic components: Sar1-GTP to initiate coat formation, Sec23/24 heterodimer to select SNARE and cargo molecules, and Sec13/31 to induce coat polymerisation and membrane deformation []. Sec23 p and Sec24p are structurally related, folding into five distinct domains: a beta-barrel, a zinc-finger (), an alpha/beta trunk domain, an all-helical region (), and a C-terminal gelsolin-like domain (). This entry describes the Sec23/24 alpha/beta trunk domain, which is formed from a single, approximately 250-residue segment plugged into the beta-barrel between strands beta-1 and beta-19. The trunk has an alpha/beta fold with a vWA topology, and it forms the dimer interface, primarily involving strand beta-14 on Sec23 and Sec24; in addition, the trunk domain of Sec23 contacts Sar1. | Short Name: | Sec23/24_trunk_dom |
| GO Term | Gene Name |
|---|---|
| GO:0006886 | IPR006896 |
| GO:0006888 | IPR006896 |
| GO:0030127 | IPR006896 |
