3 Ontology Annotations
GO Term | Gene Name |
---|---|
GO:0006886 | IPR006900 |
GO:0006888 | IPR006900 |
GO:0030127 | IPR006900 |
Type: | Domain | Name: | Sec23/Sec24, helical domain |
Description: | COPII (coat protein complex II)-coated vesicles carry proteins from the endoplasmic reticulum (ER) to the Golgi complex []. COPII-coated vesicles form on the ER by the stepwise recruitment of three cytosolic components: Sar1-GTP to initiate coat formation, Sec23/24 heterodimer to select SNARE and cargo molecules, and Sec13/31 to induce coat polymerisation and membrane deformation []. Sec23 p and Sec24p are structurally related, folding into five distinct domains: a beta-barrel, a zinc-finger (), an alpha/beta trunk domain (), an all-helical region, and a C-terminal gelsolin-like domain (). This entry describes the all-helical domain, which forms an approximately 105-residue segment with the C-terminal 30 residues. The linker between alpha-M and alpha-N contacts Sar1. | Short Name: | Sec23/24_helical_dom |
GO Term | Gene Name |
---|---|
GO:0006886 | IPR006900 |
GO:0006888 | IPR006900 |
GO:0030127 | IPR006900 |