| Type: | Family | Name: | Tctex-1 |
| Description: | Tctex-1 is a dynein light chain. Dynein translocates rhodopsin-bearing vesicles along microtubules and it has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. An efficient vectorial transport system must be required to deliver large numbers of newly synthesized rhodopsin molecules (~107molecules per day per photoreceptor) to the base of the outer segment of the photoreceptor, Tctex-1 may well play a role in this process. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit the interaction between Tctex-1 and rhodopsin, which may be the molecular basis ofretinitis pigmentosa.In the mouse, the chromosomal location and pattern of expression of Tctex-1 make it a candidate for involvement in male sterility []. | Short Name: | Tctex |
