Protein Domain : IPR011333

Type:  Domain Name:  POZ domain
Description:  The BTB (for BR-C, ttk and bab) [] or POZ (for Pox virus and Zinc finger) [, ] domain is a versatile protein-protein interaction motif involved in many cellular functions, including transcriptional regulation, cytoskeleton dynamics, ion channel assembly and gating, and targeting proteins for ubiquitination []. The BTB domain can occur alongside other domains: BTB-zinc finger (BTB-ZF), BTB-BACK-Kelch (BBK), voltage-gated potassium channel T1 (T1-Kv) [], MATH-BTB, BTB-NPH3 and BTB-BACK-PHR (BBP). Other proteins, such as Skp1 and ElonginC, consist almost exclusively of the core BTB fold. In all of these protein families, the BTB core fold is structurally conserved, consisting of a 2-layer alpha/beta topology where a cluster of alpha helices is flanked by short beta-sheets []. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [, , ]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.This entry differs from IPR000210 in including POZ-containing Skp1 proteins. Short Name:  POZ_dom
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1 Child Features

DB identifier Type Name
IPR000210 Domain BTB/POZ domain

1 Contains

DB identifier Type Name
IPR016073 Domain SKP1 component, POZ domain

1 Cross References

Identifier
SSF54695

8 Found Ins

DB identifier Type Name
IPR016897 Family S-phase kinase-associated protein 1
IPR020467 Family Potassium channel, voltage dependent, Kv1.4
IPR005404 Family Potassium channel, voltage dependent, Kv3.3
IPR004049 Family Potassium channel, voltage dependent, Kv1.2
IPR003972 Family Potassium channel, voltage dependent, Kv1
IPR004048 Family Potassium channel, voltage dependent, Kv1.1
IPR004050 Family Potassium channel, voltage dependent, Kv1.3
IPR004350 Family Potassium channel, voltage dependent, Kv2.1

0 GO Annotation

0 Ontology Annotations

0 Parent Features

45262 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
267336 D8RFV0 PAC:15410499 Selaginella moellendorffii 405  
231529 D8RHM9 PAC:15417490 Selaginella moellendorffii 603  
231523 D8RHK3 PAC:15417481 Selaginella moellendorffii 453  
93693 D8RGD8 PAC:15422866 Selaginella moellendorffii 655  
96367 D8RLF1 PAC:15406973 Selaginella moellendorffii 99  
438140 D8QUD1 PAC:15418881 Selaginella moellendorffii 792  
78850 D8QVD3 PAC:15402290 Selaginella moellendorffii 334  
98727 D8RNY6 PAC:15415929 Selaginella moellendorffii 137  
99084 PAC:15413642 Selaginella moellendorffii 835  
13821 D8RVP7 PAC:15411457 Selaginella moellendorffii 330  
141980 D8QX13 PAC:15413645 Selaginella moellendorffii 631  
270367 D8QYF8 PAC:15419593 Selaginella moellendorffii 450  
438494 D8QYH5 PAC:15421169 Selaginella moellendorffii 259  
58268 D8RYU9 PAC:15405626 Selaginella moellendorffii 141  
271223 D8S106 PAC:15421534 Selaginella moellendorffii 157  
443336 D8S0J2 PAC:15412969 Selaginella moellendorffii 413  
107813 D8S3G9 PAC:15401376 Selaginella moellendorffii 435  
438759 D8QZ68 PAC:15423362 Selaginella moellendorffii 442  
81263 D8QYY5 PAC:15406747 Selaginella moellendorffii 488  
82941 D8R0U7 PAC:15415080 Selaginella moellendorffii 493  
115371 D8SEZ0 PAC:15421297 Selaginella moellendorffii 290  
421407 D8SF66 PAC:15415761 Selaginella moellendorffii 490  
115864 D8SFP2 PAC:15402811 Selaginella moellendorffii 229  
422107 D8SHD0 PAC:15416345 Selaginella moellendorffii 567  
422152 PAC:15416426 Selaginella moellendorffii 884  
156140 PAC:15406800 Selaginella moellendorffii 581  
406756 D8R2U6 PAC:15418375 Selaginella moellendorffii 756  
121159 D8SN94 PAC:15415421 Selaginella moellendorffii 459  
424061 D8SNP1 PAC:15421427 Selaginella moellendorffii 869  
407558 D8R600 PAC:15419756 Selaginella moellendorffii 678  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7958847
            7938017
            9770450
            9019154
            9765306
            9824158
            16207353
            17384421
            9917379