Protein Domain : IPR000569

Type:  Domain Name:  HECT domain
Description:  The HECT (Homologous to the E6-AP Carboxyl Terminus) domain is an around 350 amino acids motif that has been identified in proteins that all belong to aparticular E3 ubiquitin-protein ligase family []. HECT domain containing proteins accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then transfer it to target proteins. The site of ubiquitin thioester formation is a conserved cysteine residue located in the last 32-36 aa of the HECT domain []. The amino-terminal part of the HECT domain has been involved in E2 binding []. Once linked to ubiquitin, the target proteins are degraded in the 26 S proteasome. Short Name:  HECT_dom
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0 Child Features

0 Contains

4 Cross Referencess

Identifier
PF00632
PS50237
SM00119
SSF56204

1 Found In

DB identifier Type Name
IPR017134 Family Ubiquitin-protein ligase E6-AP

1 GO Annotation

GO Term Gene Name
GO:0004842 IPR000569

1 Ontology Annotations

GO Term Gene Name
GO:0004842 IPR000569

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
3542 D8RM88 PAC:15413740 Selaginella moellendorffii 298  
443962 D8S5V8 PAC:15417621 Selaginella moellendorffii 1028  
111765 D8S989 PAC:15412767 Selaginella moellendorffii 119  
154179 D8SC62 PAC:15423310 Selaginella moellendorffii 3545  
50844 D8SEY7 PAC:15409152 Selaginella moellendorffii 800  
181768 D8SQ74 PAC:15418486 Selaginella moellendorffii 355  
407700 D8R6H2 PAC:15421077 Selaginella moellendorffii 747  
89794 D8RBF5 PAC:15411807 Selaginella moellendorffii 1088  
76253 D8QTQ2 PAC:15414277 Selaginella moellendorffii 414  
73381 PAC:15406224 Selaginella moellendorffii 354  
146155 D8RDD0 PAC:15421933 Selaginella moellendorffii 1827  
evm.TU.contig_41807.1 PAC:16431655 Carica papaya 217  
evm.model.supercontig_114.47 PAC:16406139 Carica papaya 1297  
evm.model.supercontig_146.73 PAC:16409166 Carica papaya 1003  
evm.model.supercontig_21.42 PAC:16413553 Carica papaya 3387  
evm.model.supercontig_37.145 PAC:16418598 Carica papaya 1845  
evm.model.supercontig_3792.1 PAC:16418841 Carica papaya 634  
evm.model.supercontig_5.113 PAC:16421211 Carica papaya 1161  
evm.model.supercontig_75.110 PAC:16425830 Carica papaya 109  
evm.model.supercontig_959.1 PAC:16428944 Carica papaya 2010  
29805.m001489 B9SGR6 PAC:16809195 Ricinus communis 1561  
29815.m000491 B9SRK8 PAC:16809547 Ricinus communis 1148  
29889.m003352 B9RZW1 PAC:16812298 Ricinus communis 1067  
29596.m000712 B9SMZ3 PAC:16803408 Ricinus communis 3666  
29629.m001405 B9S9V5 PAC:16803985 Ricinus communis 3691  
29609.m000604 B9SPD3 PAC:16803633 Ricinus communis 367  
29609.m000603 B9SPD2 PAC:16803632 Ricinus communis 140  
29206.m000140 PAC:16802454 Ricinus communis 875  
29602.m000214 B9SXV1 PAC:16803534 Ricinus communis 1899  
Cucsa.002040.1 PAC:16950899 Cucumis sativus 87  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7708685
            9182527