Protein Domain : IPR020588

Type:  Domain Name:  DNA recombination and repair protein RecA-like, ATP-binding domain
Description:  The recA gene product is a multifunctional enzyme that plays a role in homologous recombination, DNA repair and induction of the SOS response []. In homologous recombination, the protein functions as a DNA-dependent ATPase, promoting synapsis, heteroduplex formation and strand exchange between homologous DNAs []. RecA also acts as a protease cofactor that promotes autodigestion of the lexA product and phage repressors. The proteolytic inactivation of the lexA repressor by an activated form of recA may cause a derepression of the 20 or so genes involved in the SOS response, which regulates DNA repair, induced mutagenesis, delayed cell division and prophage induction in response to DNA damage []. RecA is a protein of about 350 amino-acid residues. Its sequence is very well conserved [, , ] among eubacterial species. It is also found in the chloroplast of plants []. RecA-like proteins are found in archaea and diverse eukaryotic organisms, like fission yeast, mouse or human. In the filamentvisualised by X-ray crystallography, beta-strand 3, the loop C-terminal to beta-strand 2, and alpha-helix D of the core domain form one surface that packs against alpha-helix A and beta-strand 0 (the N-terminal domain) of an adjacent monomer during polymerisation []. The core ATP-binding site domain is well conserved, with 14 invariant residues. It contains the nucleotide binding loop between beta-strand 1 andalpha-helix C. The Escherichia colisequence GPESSGKT matches the consensus sequence of amino acids (G/A)XXXXGK(T/S) for the Walker A box (also referred to as the P-loop) found in a number of nucleoside triphosphate (NTP)-binding proteins. Anothernucleotide binding motif, the Walker B box is found at beta-strand 4 in the RecA structure. The Walker B box is characterised by four hydrophobic amino acids followed by an acidic residue (usually aspartate). Nucleotide specificity and additional ATP binding interactions are contributed by the amino acid residues at beta-strand 2 and the loop C-terminal to thatstrand, all of which are greater than 90% conserved among bacterial RecA proteins.This entry represents the ATP-binding domain found in the N-terminal part of RecA proteins. Short Name:  RecA_ATP-bd
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0 Child Features

0 Contains

1 Cross References

Identifier
PS50162

9 Found Ins

DB identifier Type Name
IPR013765 Family DNA recombination and repair protein RecA
IPR013632 Domain DNA recombination and repair protein Rad51, C-terminal
IPR016467 Family DNA recombination and repair protein, RecA-like
IPR011940 Family Meiotic recombinase Dmc1
IPR011939 Family DNA repair and recombination protein RadB
IPR011938 Family DNA recombination/repair protein RadA
IPR022373 Family KaiC domain-containing protein
IPR022420 Family Circadian clock protein, KaiC, archaea
IPR022443 Family KaiC-related

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR020588
GO:0005524 IPR020588
GO:0008094 IPR020588
GO:0006281 IPR020588

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR020588
GO:0005524 IPR020588
GO:0008094 IPR020588
GO:0006281 IPR020588

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
98813 D8RQV9 PAC:15416593 Selaginella moellendorffii 588  
101803 D8RUK2 PAC:15406120 Selaginella moellendorffii 202  
80718 D8QXT4 PAC:15407466 Selaginella moellendorffii 235  
73323 D8QP42 PAC:15406073 Selaginella moellendorffii 336  
408953 D8R902 PAC:15403327 Selaginella moellendorffii 453  
evm.model.supercontig_10.24 PAC:16404604 Carica papaya 449  
evm.model.supercontig_139.41 PAC:16408540 Carica papaya 343  
evm.model.supercontig_18.103 PAC:16411242 Carica papaya 346  
evm.model.supercontig_182.28 PAC:16411579 Carica papaya 368  
evm.model.supercontig_25.37 PAC:16414830 Carica papaya 202  
evm.model.supercontig_252.16 PAC:16414937 Carica papaya 168  
evm.model.supercontig_344.4 PAC:16418081 Carica papaya 340  
evm.model.supercontig_44.128 PAC:16420133 Carica papaya 333  
evm.model.supercontig_61.12 PAC:16423826 Carica papaya 393  
evm.model.supercontig_63.24 PAC:16424112 Carica papaya 139  
evm.model.supercontig_95.51 PAC:16428893 Carica papaya 299  
29739.m003680 B9RR28 PAC:16807459 Ricinus communis 294  
29788.m000324 B9SYN5 PAC:16808534 Ricinus communis 315  
29844.m003214 B9RTJ3 PAC:16810921 Ricinus communis 353  
29912.m005338 B9RK79 PAC:16813216 Ricinus communis 380  
30053.m000104 B9T6M8 PAC:16816117 Ricinus communis 388  
30174.m008856 B9RDA0 PAC:16822501 Ricinus communis 346  
29582.m000250 B9T088 PAC:16803106 Ricinus communis 301  
29650.m000274 B9SVD4 PAC:16804871 Ricinus communis 343  
Cucsa.379800.1 PAC:16982167 Cucumis sativus 328  
Cucsa.373370.1 PAC:16981849 Cucumis sativus 130  
Cucsa.040390.1 PAC:16952765 Cucumis sativus 410  
Cucsa.040390.2 PAC:16952766 Cucumis sativus 320  
Cucsa.021670.1 A0A0A0LBL7 PAC:16951915 Cucumis sativus 630  
Cucsa.051670.1 PAC:16954235 Cucumis sativus 359  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7592482
            8587109
            1896024
            1518831
            9187054
            12045091