1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR011991 | Domain | Winged helix-turn-helix DNA-binding domain |
| Type: | Domain | Name: | RNA-binding protein Lupus La |
| Description: | Human Ro ribonucleoproteins (RNPs) are composed of one of the four small Y RNAs and at least two proteins, Ro60 and La. The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjogren's syndrome []. In the nucleus, La acts as a RNA polymerase III (RNAP III) transcription factor, while in the cytoplasm, La acts as a translation factor []. In the nucleus, La binds to the 3'UTR of nascent RNAP III transcripts to assist in folding and maturation []. In the cytoplasm, La recognises specific classes of mRNAs that contain a 5'-terminal oligopyrimidine (5'TOP) motif known to control protein synthesis []. The specific recognition is mediated by the N-terminal domain of La, which comprises a La motif and a RNA recognition motif (RRM). The La motif adopts an alpha/beta fold that comprises a winged-helix motif [].Homologous La domain-containing proteins have been identified in a wide range of organisms except Archaea, bacteria and viruses []. | Short Name: | Lupus_La_RNA-bd |
| DB identifier | Type | Name |
|---|---|---|
| IPR011991 | Domain | Winged helix-turn-helix DNA-binding domain |
