| Type: | Family | Name: | Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase |
| Description: | Lecithin:cholesterol acyltransferase (LACT), also known as phosphatidylcholine-sterol acyltransferase (), is involved in extracellular metabolism of plasma lipoproteins, including cholesterol. It esterifies the free cholesterol transported in plasma lipoproteins, and is activated by apolipoprotein A-I. Defects in LACT cause Norum and Fish eye diseases.This family also includes phospholipid:diacylglycerol acyltransferase (PDAT)(), which is involved in triacylglycerol formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid []. | Short Name: | LACT/PDAT_acylTrfase |
