1 Found In
| DB identifier | Type | Name |
|---|---|---|
| IPR016650 | Family | Eukaryotic translation initiation factor 3 subunit E |
| Type: | Domain | Name: | Proteasome component (PCI) domain |
| Description: | A homology domain of unclear function, occurs in the C-terminal region of several regulatory components of the 26S proteasome as well as in other proteins. This domainhas also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [].Apparently, all of the characterised proteins containing PCI domains are parts of larger multi-protein complexes. Proteins with PCI domains include budding yeast proteasomeregulatory components Rpn3(Sun2), Rpn5, Rpn6, Rpn7and Rpn9 []; mammalian proteasome regulatory components p55, p58 and p44.5, and translationinitiation factor 3 complex subunits p110 and INT6 [, ]; ArabidopsisCOP9 and FUS6/COP11 []; mammalian G-protein pathway suppressor GPS1, and severaluncharacterised ORFs from plant, nematodes and mammals. The complete homology domain comprises approx. 200 residues, the highest conservation is found in the C-terminal half. Several of theproteins mentioned above have no detectable homology to the N-terminal half of the domain. | Short Name: | PCI_dom |
| DB identifier | Type | Name |
|---|---|---|
| IPR016650 | Family | Eukaryotic translation initiation factor 3 subunit E |
