| Type: | Domain | Name: | PLAT/LH2 domain |
| Description: | This entry represents a domain found in a variety of membrane or lipid associated proteins. It is known as the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain, is found in a variety of membrane or lipid associated proteins. Structurally, this domain forms a beta-sandwich composed of two sheets of four strands each [, , ]. The most highly conserved regions coincide with the beta-strands, with most of the highly conserved residues being buried within the protein. An exception to this is a surface lysine or arginine that occurs on the surface of the fifth beta-strand of the eukaryotic domains. In pancreatic lipase, the lysine in this position forms a salt bridge with the procolipase protein. The conservation of a charged surface residue may indicate the location of a conserved ligand-binding site. It is thought that this domain may mediate membrane attachment via other protein binding partners. | Short Name: | PLAT/LH2_dom |
| DB identifier | Type | Name |
|---|---|---|
| IPR000907 | Family | Lipoxygenase |
| IPR000434 | Family | Polycystic kidney disease type 1 protein |
| IPR017229 | Family | Multidomain scavenger receptor-like protein PxSR |
| IPR016272 | Family | Lipase, LIPH-type |
| IPR002330 | Family | Lipoprotein lipase |
| IPR002331 | Family | Pancreatic lipase |
| IPR002333 | Family | Hepatic lipase |
| IPR000734 | Family | Triacylglycerol lipase family |
| IPR001885 | Family | Lipoxygenase, mammalian |
