| Type: | Domain | Name: | FCP1 homology domain |
| Description: | Yeast FCP1 is an essential protein serine phosphatase () that dephosphorylates the C-terminal domain (CTD) of RNA polymerase II. FCP1 orthologs are present in all known eukaryote proteomes. The N-terminal domain of FCP1 corresponds to the catalytic unit of the phosphatase and has been refered to as the FCP1 homology domain. The FCP1 homology domain, which is a ~180-residue module, is also found in many other proteins of unknown function. It contains a DxDx(T/V) motif preceded by four hydrophobic residues characteristic of a large family of metal-dependent phosphohydrolases andphosphotransferases. The first aspartate residue is likely to participate in catalysis, whereas the second could have a role in substrate recognition[, , , ]. | Short Name: | FCP1_dom |
