Type: | Domain | Name: | SGNH hydrolase-type esterase domain |
Description: | This entry represents the SGNH hydrolase-type esterase domain, which has a similar fold to flavoproteins, namely a three-layer alpha/beta/alpha structure, where the beta-sheets are composed of five parallel strands. Enzymes containing this domain act as esterases and lipases, but have little sequence homology to true lipases [, ]. Proteins containing this type of esterase domain have been found in a variety of hydrolases; those with structural information include an esterase from Streptomyces scabies[]; the esterase domain of viral haemagglutinin-esterase surface glycoproteins (influenza C virus, coronaviruses and toroviruses) []; mammalian acetylhydrolases []; fungal rhamnogalacturonan acetylesterase []; and the multifunctional enzyme thioesterase I (TAP) from Escherichia coli[]. SGNH hydrolase-type esterase domains contain unique hydrogen bond network that stabilises their catalytic centres; they usually contain the catalytic triad Ser/Acid/His. | Short Name: | SGNH_hydro |