Protein Domain : IPR009056

Type:  Domain Name:  Cytochrome c-like domain
Description:  After cytochrome c is synthesized in the cytoplasm as apocytochrome c, it is transported through the outer mitochondrial membrane to the intermembrane space, where haem is covalently attached by thioester bonds to two cysteine residues located in the cytochrome c centre. Cytochrome c is required during oxidative phosphorylation as an electron shuttle between Complex III (cytochrome c reductase) and IV (cytochrome c oxidase). In addition, cytochrome c is involved in apoptosis in more complex organisms such as Xenopus, rats and humans. Cellular stress can induce cytochrome c release from the mitochondrial membrane. In mammals, cytochrome c triggers the assembly of the apoptosome, consisting of cytochrome c, Apaf-1 and dATP, which activates caspase-9, leading to cell death [, ]. There are several different members of the cytochrome c family with different functional roles, for instance cytochrome c549 is associated with photosystem II []. The known structures of c-type cytochromes have six different classes of fold. Of these, four are unique to c-type cytochromes [, ]. The consensus sequence for the cytochrome c centre is Cys-X-X-Cys-His, where the histidine residue is one of the two axial ligands of the haem iron []. This arrangement is shared by all proteins known to belong to the cytochrome c family, which presently includes both mono-haem proteins and multi-haem proteins. This entry represents mono-haem cytochrome c proteins (excluding class II and f-type cytochromes), such as cytochromes c, c1, c2, c5, c555, c550 to c553, c556, and c6.Cytochrome c-type centres are also found in the active sites of many enzymes, including cytochrome cd1-nitrite reductase as the N-terminal haem c domain, in quinoprotein alcohol dehydrogenase as the C-terminal domain, in Quinohemoprotein amine dehydrogenase A chain as domains 1 and 2, and in the cytochrome bc1 complex as the cytochrome bc1 domain. Short Name:  Cyt_c-like_dom
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4 Child Features

DB identifier Type Name
IPR004852 Domain Di-haem cytochrome c peroxidase
IPR013427 Domain Haem-binding domain, putative
IPR015182 Domain Quinohemoprotein amine dehydrogenase, alpha subunit, haem binding domain
IPR029490 Domain Cytochrome c-550 domain

0 Contains

5 Cross Referencess

Identifier
PF00034
PF13442
PS51007
G3DSA:1.10.760.10
SSF46626

10 Found Ins

DB identifier Type Name
IPR002326 Family Cytochrome c1
IPR004678 Family Cytochrome c oxidase cbb3-type, subunit III
IPR021195 Family Ubiquinol cytochrome c reductase, cytochrome c1 subunit, predicted
IPR014353 Family Membrane-bound alcohol dehydrogenase, cytochrome c subunit
IPR022394 Family Methylamine utilisation protein, MauG
IPR012049 Family Menaquinone:cytochrome c reductase, cytochrome b/c subunit
IPR009152 Family Ubiquinol-cytochrome-c reductase, cytochrome c subunit
IPR010538 Family Di-haem oxidoreductase, putative peroxidase
IPR019604 Family Photosystem P840 reaction-centre, cytochrome c-551
IPR022411 Family C-type cytochrome, methanol metabolism-related

2 GO Annotations

GO Term Gene Name
GO:0009055 IPR009056
GO:0020037 IPR009056

2 Ontology Annotations

GO Term Gene Name
GO:0009055 IPR009056
GO:0020037 IPR009056

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
171122 D8RFW8 PAC:15406542 Selaginella moellendorffii 111  
411405 D8RHT8 PAC:15408449 Selaginella moellendorffii 111  
438842 D8QZU8 PAC:15401886 Selaginella moellendorffii 264  
177642 D8S7R5 PAC:15405641 Selaginella moellendorffii 296  
402553 D8QR17 PAC:15405030 Selaginella moellendorffii 601  
90767 D8RC36 PAC:15414970 Selaginella moellendorffii 114  
evm.model.supercontig_113.15 PAC:16406023 Carica papaya 112  
evm.model.supercontig_130.13 PAC:16407915 Carica papaya 310  
evm.model.supercontig_135.15 PAC:16408252 Carica papaya 175  
evm.model.supercontig_185.7 PAC:16411685 Carica papaya 116  
29733.m000752 B9S853 PAC:16807086 Ricinus communis 92  
29841.m002789 B9RUZ9 PAC:16810503 Ricinus communis 265  
30128.m008826 B9RFB0 PAC:16818414 Ricinus communis 112  
30170.m013626 B9R6R3 PAC:16821475 Ricinus communis 199  
30186.m001301 B9RPZ3 PAC:16823065 Ricinus communis 174  
30190.m010975 B9RBM7 PAC:16823338 Ricinus communis 310  
32143.m000030 B9TIT4 PAC:16825308 Ricinus communis 130  
32143.m000031 B9TIT5 PAC:16825309 Ricinus communis 199  
33500.m000029 B9TJS4 PAC:16825870 Ricinus communis 92  
34163.m000022 B9TI80 PAC:16826118 Ricinus communis 273  
34574.m000020 B9TDP8 PAC:16826267 Ricinus communis 217  
36084.m000028 B9TD11 PAC:16826864 Ricinus communis 72  
37773.m000014 PAC:16827057 Ricinus communis 143  
42064.m000025 B9TJI7 PAC:16827484 Ricinus communis 246  
42993.m000043 B9TC18 PAC:16827562 Ricinus communis 138  
52579.m000017 B9THN3 PAC:16828536 Ricinus communis 356  
56647.m000019 B9TMY8 PAC:16828953 Ricinus communis 212  
56747.m000023 B9TLJ1 PAC:16828962 Ricinus communis 170  
59962.m000019 B9TED0 PAC:16829308 Ricinus communis 353  
29354.m000028 B9TBB6 PAC:16802756 Ricinus communis 106  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12729583
            2166169
            11315568
            10707095
            12594933
            10647174