| Type: | Family | Name: | Glyoxalase I |
| Description: | Glyoxalase I (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway in the following reaction:glutathione + methylglyoxal = (R)-S-lactoylglutathione S-lactoylglutathione is then converted by glyoxalase II to lactic acid [].Glyoxalase I is a ubiquitous enzyme which binds one mole of zinc per subunit. The bacterial and yeast enzymes are monomeric while the mammalianone is homodimeric. The sequence of glyoxalase I is well conserved. In bacteria and mammals theenzyme is a protein of about 130 to 180 residues while in fungi it is about twice as long. In these organisms the enzyme is built out of the tandem repeatof a homologous domain. | Short Name: | Glyoxalase_1 |
