| Type: | Domain | Name: | F-box domain |
| Description: | First identified in cyclin-F as a protein-protein interaction motif, the F-box is a conserved domain that is present in numerous protein with a bipartitestructure []. Through the F-box, these proteins are linked to the Skp1protein and the core of SCFs (Skp1-cullin-F-box protein ligase) complexes. SCFs complexes constitute a new class of E3 ligases []. They function incombination with the E2 enzyme Cdc34 to ubiquitinate G1 cyclins, Cdk inhibitors and many other proteins, to mark them for degradation. The bindingof the specific substrates by SCFs complexes is mediated by divergent protein- protein interaction motifs present in F-box proteins, like WD40 repeats, leucine rich repeats [, ] or ANK repeats. | Short Name: | F-box_dom |
