Protein Domain : IPR001537

Type:  Domain Name:  tRNA/rRNA methyltransferase, SpoU type
Description:  This entry represents a domain found in the spoU protein from E. coli that shows strong similarities to previously characterised 2'-O-methyltransferases [, ]. The Mrm1 protein of Saccharomyces cerevisiae has been shown to be required for ribose methylation at a universally conserved nucleotide in the peptidyl transferase centre of the mitochondrial large ribosomal RNA (21S rRNA). Cells reduced in this activity were deficient in formation of functional large subunits of the mitochondrial ribosome. The Mrm1 protein catalyzes the site-specific formation of 2'-O-methylguanosine on in vitrotranscripts of both mitochondrial 21S rRNA and E. coli 23S rRNA providing evidence for an essential modified nucleotide in rRNA []. Short Name:  SpoU_MeTrfase
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0 Child Features

0 Contains

1 Cross References

Identifier
PF00588

4 Found Ins

DB identifier Type Name
IPR004441 Family RNA methyltransferase TrmH family
IPR004384 Family RNA methyltransferase TrmH, group 1
IPR016914 Family tRNA (cytidine/uridine-2'-O-)-methyltransferase
IPR016479 Family tRNA/rRNA methyltransferase, YfiF, predicted

3 GO Annotations

GO Term Gene Name
GO:0003723 IPR001537
GO:0008173 IPR001537
GO:0006396 IPR001537

3 Ontology Annotations

GO Term Gene Name
GO:0003723 IPR001537
GO:0008173 IPR001537
GO:0006396 IPR001537

1 Parent Features

DB identifier Type Name
IPR029026 Domain tRNA (guanine-N1-)-methyltransferase, N-terminal

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
35012 D8RG29 PAC:15403103 Selaginella moellendorffii 240  
415294 D8RVN0 PAC:15418936 Selaginella moellendorffii 338  
119049 D8SK11 PAC:15408344 Selaginella moellendorffii 264  
67834 D8R3B3 PAC:15414578 Selaginella moellendorffii 157  
86381 D8R5A1 PAC:15422111 Selaginella moellendorffii 220  
3012 D8QPV3 PAC:15409740 Selaginella moellendorffii 244  
77463 D8QT02 PAC:15418693 Selaginella moellendorffii 321  
77385 D8QRC1 PAC:15417946 Selaginella moellendorffii 186  
evm.model.supercontig_14.138 PAC:16408634 Carica papaya 360  
evm.model.supercontig_16.75 PAC:16410112 Carica papaya 218  
evm.model.supercontig_234.12 PAC:16414392 Carica papaya 143  
evm.model.supercontig_234.13 PAC:16414393 Carica papaya 139  
evm.model.supercontig_2698.1 PAC:16415466 Carica papaya 180  
evm.model.supercontig_40.94 PAC:16419501 Carica papaya 394  
evm.model.supercontig_55.6 PAC:16422627 Carica papaya 360  
29726.m003948 B9RSV9 PAC:16806661 Ricinus communis 216  
29738.m000999 B9SEE0 PAC:16807290 Ricinus communis 1744  
29912.m005432 B9RKH2 PAC:16813309 Ricinus communis 517  
30152.m002400 B9RHG3 PAC:16820690 Ricinus communis 234  
35636.m000023 B9TJB1 PAC:16826686 Ricinus communis 259  
28124.m000237 B9T3S9 PAC:16799976 Ricinus communis 334  
29235.m000234 B9T2B4 PAC:16802529 Ricinus communis 342  
Cucsa.338500.1 A0A0A0LC15 PAC:16978758 Cucumis sativus 370  
Cucsa.321350.1 PAC:16977486 Cucumis sativus 1804  
Cucsa.050180.1 A0A0A0K6L9 PAC:16954086 Cucumis sativus 268  
Cucsa.253780.1 PAC:16972150 Cucumis sativus 218  
Cucsa.260180.1 PAC:16973128 Cucumis sativus 331  
Cucsa.260180.2 PAC:16973129 Cucumis sativus 328  
Cucsa.288820.1 PAC:16975132 Cucumis sativus 512  
orange1.1g025787m A0A067GBI0 PAC:18134982 Citrus sinensis 248  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8265370
            9321663
            8266080