Protein Domain : IPR001972

Type:  Family Name:  Stomatin family
Description:  Stomatin is also known as erythrocyte membrane protein band 7.2b. It is a 31 kDa membrane protein [], and was named after the rare human disease: haemolytic anaemia hereditary stomatocytosis. Stomatin is believed to be involved in regulating monovalent cation transport through lipid membranes. Absence of the protein in hereditary stomatocytosis is believed to be the reason for the leakage of Na+and K+ions into and from erythrocytes []. Stomatin is also expressed in mechanosensory neurons, where it may interact directly with transduction components, including cation channels [].Stomatin proteins have been identified in various organisms, including Caenorhabditis elegans. There are nine stomatin-like proteins in C. elegans, MEC-2 being the one best characterised []. In mammals, other stomatin family members are stomatin-like proteins SLP1, SLP2 and SLP3, and NPHS2 (podocin), which display selective expression patterns []. Stomatin family members are oligomeric, they mostly localise to membrane domains, and in many cases have been shown to modulate ion channel activity. Short Name:  Stomatin_fam
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13 Child Features

DB identifier Type Name
IPR010201 Family HflK
IPR010200 Family HflC
IPR028525 Family Stomatin-2
IPR028527 Family Stomatin-3
IPR028522 Family Protein Unc-1
IPR028528 Family Stomatin-4
IPR028529 Family Mechanosensory protein 2
IPR028513 Family Stomatin-1
IPR028515 Family Erythrocyte band 7 integral membrane protein (Stomatin)
IPR028512 Family Hypersensitive-induced response protein
IPR028517 Family Stomatin-like protein 1
IPR028519 Family Stomatin-like protein 3
IPR028509 Family Podocin

2 Contains

DB identifier Type Name
IPR020980 Domain Menbrane protein HflK, N-terminal
IPR018080 Conserved_site Band 7/stomatin-like, conserved site

2 Cross Referencess

Identifier
PTHR10264
PR00721

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0016020 IPR001972

1 Ontology Annotations

GO Term Gene Name
GO:0016020 IPR001972

1 Parent Features

DB identifier Type Name
IPR001107 Family Band 7 protein

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
270221 D8QNF6 PAC:15418741 Selaginella moellendorffii 359  
140325 D8QTH7 PAC:15405881 Selaginella moellendorffii 286  
269623 D8T3L8 PAC:15418592 Selaginella moellendorffii 286  
evm.model.supercontig_17.204 PAC:16410705 Carica papaya 285  
evm.model.supercontig_3.176 PAC:16416453 Carica papaya 431  
evm.model.supercontig_3.279 PAC:16416567 Carica papaya 249  
evm.model.supercontig_5.273 PAC:16421388 Carica papaya 286  
29736.m002035 B9S2B7 PAC:16807140 Ricinus communis 285  
29822.m003472 B9RUM4 PAC:16809841 Ricinus communis 254  
30147.m014184 B9R9P0 PAC:16820196 Ricinus communis 291  
30154.m001127 B9S0U2 PAC:16820758 Ricinus communis 405  
33505.m000027 B9TH94 PAC:16825873 Ricinus communis 180  
45029.m000019 B9TQB0 PAC:16827765 Ricinus communis 153  
Cucsa.005500.2 Q6UNT3 PAC:16951160 Cucumis sativus 284  
Cucsa.005500.3 Q6UNT3 PAC:16951161 Cucumis sativus 284  
Cucsa.005500.1 Q6UNT3 PAC:16951159 Cucumis sativus 284  
Cucsa.115690.2 PAC:16960505 Cucumis sativus 252  
Cucsa.115690.1 A0A0A0KL77 PAC:16960504 Cucumis sativus 291  
Cucsa.174720.1 PAC:16966703 Cucumis sativus 424  
Cucsa.197530.3 A0A0A0LUG0 PAC:16968443 Cucumis sativus 286  
Cucsa.197530.1 A0A0A0LUG0 PAC:16968441 Cucumis sativus 286  
Cucsa.197530.2 A0A0A0LUG0 PAC:16968442 Cucumis sativus 286  
Cucsa.251450.1 PAC:16971791 Cucumis sativus 302  
orange1.1g038305m A0A067D9J3 PAC:18131548 Citrus sinensis 414  
orange1.1g023266m A0A067G8R0 PAC:18119015 Citrus sinensis 285  
orange1.1g024967m A0A067G8Y3 PAC:18119016 Citrus sinensis 260  
orange1.1g023287m A0A067GAQ3 PAC:18135067 Citrus sinensis 284  
orange1.1g023168m A0A067G248 PAC:18135040 Citrus sinensis 286  
orange1.1g022890m A0A067FQD5 PAC:18127848 Citrus sinensis 290  
orange1.1g029372m PAC:18102456 Citrus sinensis 194  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9147127
            15471860
            12239636
            21501885