Protein Domain : IPR012133

Type:  Family Name:  Alpha-hydroxy acid dehydrogenase, FMN-dependent
Description:  This group represents an alpha-hydroxy acid dehydrogenase, which is FMN-dependent. Human glycolate oxidase (GO) catalyses the FMN-dependent oxidation of glycolate to glyoxylate and glyoxylate to oxalate. The latter is a key metabolite in kidney stone formation. 4-carboxy-5-dodecylsulphanyl-1,2,3-triazole (CDST) is an inhibiter of this enzyme. In contrast to most alpha-hydroxy acid oxidases, including spinach glycolate oxidase, a loop region, known as loop 4, is completely visible when the GO active site contains a small ligand. Since this is an unique structural feature, it has the potential to be a target for drugs to decrease glycolate and glyoxylate levels in primary hyperoxaluria type 1 patients who have the inability to convert peroxisomal glyoxylate to glycine []. In addition, L-Lactate oxidase (LOX) belongs to a family of flavin mononucleotide (FMN)-dependent alpha-hydroxy acid-oxidizing enzymes []. Short Name:  Alpha-hydoxy_acid_DH_FMN
Paste the following link

3 Child Features

DB identifier Type Name
IPR014080 Family L-lactate oxidase
IPR020920 Family L-lactate dehydrogenase, bacterial
IPR023989 Family Heme/flavin dehydrogenase, Rv0694

1 Contains

DB identifier Type Name
IPR008259 Active_site FMN-dependent alpha-hydroxy acid dehydrogenase, active site

2 Cross Referencess

Identifier
PIRSF000138
PS51349

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0010181 IPR012133
GO:0016491 IPR012133
GO:0055114 IPR012133

3 Ontology Annotations

GO Term Gene Name
GO:0010181 IPR012133
GO:0016491 IPR012133
GO:0055114 IPR012133

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
266585 D8QNN2 PAC:15409182 Selaginella moellendorffii 371  
402239 D8QQ12 PAC:15402693 Selaginella moellendorffii 375  
evm.model.supercontig_17.9 PAC:16410816 Carica papaya 368  
evm.model.supercontig_25.151 PAC:16414747 Carica papaya 333  
evm.model.supercontig_77.100 PAC:16426055 Carica papaya 348  
29727.m000481 B9ST69 PAC:16806853 Ricinus communis 364  
29727.m000482 B9ST70 PAC:16806854 Ricinus communis 300  
29727.m000485 B9ST73 PAC:16806857 Ricinus communis 146  
29727.m000486 B9ST74 PAC:16806858 Ricinus communis 364  
29727.m000487 B9ST75 PAC:16806859 Ricinus communis 364  
29693.m001985 B9S0Y9 PAC:16805955 Ricinus communis 369  
Cucsa.047810.1 PAC:16953746 Cucumis sativus 367  
Cucsa.047810.2 PAC:16953747 Cucumis sativus 367  
Cucsa.047810.3 PAC:16953748 Cucumis sativus 367  
Cucsa.047810.4 PAC:16953749 Cucumis sativus 367  
Cucsa.149410.6 PAC:16964270 Cucumis sativus 299  
Cucsa.149410.7 PAC:16964271 Cucumis sativus 260  
Cucsa.149420.1 A0A0A0LBZ1 PAC:16964272 Cucumis sativus 368  
Cucsa.149400.1 PAC:16964264 Cucumis sativus 364  
Cucsa.149410.1 PAC:16964265 Cucumis sativus 343  
Cucsa.149410.5 PAC:16964269 Cucumis sativus 313  
orange1.1g028827m A0A067DBU7 PAC:18122320 Citrus sinensis 203  
orange1.1g028838m A0A067DBU7 PAC:18122321 Citrus sinensis 203  
orange1.1g026380m A0A067D0J9 PAC:18122317 Citrus sinensis 239  
orange1.1g026391m A0A067D0J9 PAC:18122318 Citrus sinensis 239  
orange1.1g026410m A0A067D0J9 PAC:18122319 Citrus sinensis 239  
orange1.1g024846m A0A067DBU3 PAC:18122316 Citrus sinensis 261  
orange1.1g039466m A0A067DB37 PAC:18095998 Citrus sinensis 263  
orange1.1g017433m A0A067GF36 PAC:18112225 Citrus sinensis 371  
orange1.1g021739m A0A067GSE3 PAC:18112226 Citrus sinensis 308  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18215067
            18367206