Protein Domain : IPR027443

Type:  Domain Name:  Isopenicillin N synthase-like
Description:  Isopenicillin N synthase (IPNS) catalyses conversion of the linear tripeptide delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-valine (ACV) to isopenicillin N (IPN), the central step in biosynthesis of the beta-lactam antibiotics. IPNS is a nonhaem-Fe2+-dependent enzyme. It belongs to a class of nonhaem Fe2+-containing enzymes which includes 2-oxoglutarate-dependent dioxygenases, 2-oxoglutarate-dependent hydroxy- lases, and enzymes involved in ethylene formation and anthocyaninidin biosynthesis.The IPNS structure shows that the active site is buried within the hydrophobic pocket of an eight-stranded jelly roll barrel [, ]. Short Name:  IPNS-like

0 Child Features

0 Contains

1 Cross References

Identifier
G3DSA:2.60.120.330

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

39395 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
92217 D8RFW5 PAC:15416822 Selaginella moellendorffii 347  
37413 D8QUQ7 PAC:15412107 Selaginella moellendorffii 93  
413285 D8RNY9 PAC:15413082 Selaginella moellendorffii 307  
413284 D8RNY8 PAC:15413079 Selaginella moellendorffii 167  
414251 PAC:15415918 Selaginella moellendorffii 158  
3309 D8TFH5 PAC:15412053 Selaginella moellendorffii 182  
101166 PAC:15423184 Selaginella moellendorffii 332  
414516 PAC:15418071 Selaginella moellendorffii 186  
442385 D8RT01 PAC:15410168 Selaginella moellendorffii 354  
270397 D8QX75 PAC:15419670 Selaginella moellendorffii 336  
71477 D8QX68 PAC:15423378 Selaginella moellendorffii 77  
79989 PAC:15406026 Selaginella moellendorffii 356  
80493 D8QWI5 PAC:15405419 Selaginella moellendorffii 334  
443154 D8RZ20 PAC:15411498 Selaginella moellendorffii 302  
105948 A9LY20 PAC:15418758 Selaginella moellendorffii 397  
416774 D8S0D5 PAC:15403174 Selaginella moellendorffii 173  
3987 PAC:15416830 Selaginella moellendorffii 276  
109178 D8S5M9 PAC:15402039 Selaginella moellendorffii 491  
418618 D8S6L6 PAC:15408114 Selaginella moellendorffii 164  
406018 PAC:15412923 Selaginella moellendorffii 163  
438734 D8QZ23 PAC:15423306 Selaginella moellendorffii 344  
271401 D8S8S1 PAC:15423003 Selaginella moellendorffii 350  
116278 PAC:15423470 Selaginella moellendorffii 269  
116993 D8SHD9 PAC:15406586 Selaginella moellendorffii 329  
422116 D8SHE0 PAC:15416364 Selaginella moellendorffii 265  
422093 PAC:15415822 Selaginella moellendorffii 192  
228878 D8SHD8 PAC:15410888 Selaginella moellendorffii 329  
179875 D8SIJ4 PAC:15413209 Selaginella moellendorffii 345  
422739 PAC:15420958 Selaginella moellendorffii 530  
422734 PAC:15420954 Selaginella moellendorffii 186  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12926272
            10422580