Protein Domain : IPR008050

Type:  Family Name:  DNA replication licensing factor Mcm7
Description:  The MCM2-7 complex consists of six closely related proteins that are highly conserved throughout the eukaryotic kingdom. In eukaryotes, Mcm7 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring []. MCM2-7 complex is part of the pre-replication complex (pre-RC). In G1 phase, inactive MCM2-7 complex is loaded onto origins of DNA replication [, , ]. During G1-S phase, MCM2-7 complex is activated to unwind the double stranded DNA and plays an important role in DNA replication forks elongation [].The components of the MCM2-7 complex are: DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, DNA replication licensing factor MCM5, DNA replication licensing factor MCM6, DNA replication licensing factor MCM7, The human MCM7 gene has been localised to chromosome 7q21.3-q22.1. Increased expression of Mcm7 RNA and protein in MYCN-amplified neuroblastoma tumour and cell lines hasbeen reported []. Furthermore, The Mcm7 protein has been shown to formcomplexes with the retinoblastoma protein []. These findings suggest Mcm7-directed DNA replication contributes to neoplastic transformation. Short Name:  MCM7
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0 Child Features

2 Contains

DB identifier Type Name
IPR012340 Domain Nucleic acid-binding, OB-fold
IPR018525 Conserved_site Mini-chromosome maintenance, conserved site

2 Cross Referencess

Identifier
PTHR11630:SF26
PR01663

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0003677 IPR008050
GO:0003678 IPR008050
GO:0005524 IPR008050
GO:0006270 IPR008050
GO:0005634 IPR008050
GO:0042555 IPR008050

6 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR008050
GO:0003678 IPR008050
GO:0005524 IPR008050
GO:0006270 IPR008050
GO:0005634 IPR008050
GO:0042555 IPR008050

0 Parent Features

413 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
163959 D8QQX4 PAC:15411489 Selaginella moellendorffii 750  
evm.model.supercontig_18.41 PAC:16411427 Carica papaya 716  
30076.m004661 B9RNE8 PAC:16817271 Ricinus communis 718  
Cucsa.205060.1 A0A0A0K9I6 PAC:16969050 Cucumis sativus 724  
orange1.1g005024m A0A067H4R2 PAC:18137259 Citrus sinensis 718  
AT4G02060.2 P43299 PAC:19646641 Arabidopsis thaliana 716  
AT4G02060.1 P43299 PAC:19646640 Arabidopsis thaliana 716  
Thhalv10028471m V4L6C1 PAC:20197323 Eutrema salsugineum 716  
Ciclev10019324m V4U147 PAC:20810238 Citrus clementina 619  
Lus10001452 PAC:23161030 Linum usitatissimum 720  
Lus10002427 PAC:23179437 Linum usitatissimum 720  
Potri.014G121000.1 B9I9J1 PAC:27035511 Populus trichocarpa 718  
Gorai.004G144300.1 A0A0D2MY92 PAC:26775802 Gossypium raimondii 494  
Gorai.007G123000.2 A0A0D2QRB4 PAC:26782617 Gossypium raimondii 619  
Gorai.007G123000.1 A0A0D2P7S3 PAC:26782616 Gossypium raimondii 718  
39003 I0Z9G6 PAC:27389370 Coccomyxa subellipsoidea C-169 683  
49470 C1ML69 PAC:27343279 Micromonas pusilla CCMP1545 723  
113427 C1FD42 PAC:27399462 Micromonas sp RCC299 747  
48809 A4RSQ3 PAC:27414632 Ostreococcus lucimarinus 717  
Thecc1EG004805t1 A0A061DR41 PAC:27433331 Theobroma cacao 718  
Thecc1EG004805t2 A0A061DRD4 PAC:27433332 Theobroma cacao 612  
Thecc1EG004805t3 A0A061DT56 PAC:27433333 Theobroma cacao 564  
Migut.D00627.1.p A0A022S1V0 PAC:28928958 Mimulus guttatus 718  
Migut.K01491.1.p A0A022R7I7 PAC:28936862 Mimulus guttatus 247  
Migut.K01501.1.p PAC:28937340 Mimulus guttatus 354  
Migut.K01506.1.p PAC:28938151 Mimulus guttatus 295  
Migut.L00246.1.p A0A022Q035 PAC:28935623 Mimulus guttatus 696  
Migut.L00822.1.p PAC:28935003 Mimulus guttatus 398  
Araha.1807s0005.1.p PAC:28863633 Arabidopsis halleri 716  
Cagra.0753s0036.1.p PAC:28902552 Capsella grandiflora 617  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            19896182
            19910535
            22841721
            17506634
            9566894
            11861392