Protein Domain : IPR000866

Type:  Domain Name:  Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Description:  Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant enzymes that also control cytokine-induced peroxide levels which mediate signal transduction in mammalian cells. Prxs can be regulated by changes to phosphorylation, redox and possibly oligomerisation states. Prxs are divided into three classes: typical 2-Cys Prxs; atypical 2-Cys Prxs; and 1-Cys Prxs. All Prxs share the same basic catalytic mechanism, in which an active-site cysteine (the peroxidatic cysteine) is oxidised to a sulphenic acid by the peroxide substrate. The recycling of the sulphenic acid back to a thiol is what distinguishes the three enzyme classes. Using crystal structures, a detailed catalytic cycle has been derived for typical 2-Cys Prxs, including a model for the redox-regulated oligomeric state proposed to control enzyme activity [].Alkyl hydroperoxide reductase (AhpC) is responsible for directly reducing organic hyperoxides in its reduced dithiol form. Thiol specific antioxidant (TSA) is a physiologically important antioxidant which constitutes an enzymatic defence against sulphur-containing radicals. This family contains AhpC and TSA, as well as related proteins. Short Name:  AhpC/TSA
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0 Child Features

0 Contains

1 Cross References

Identifier
PF00578

2 Found Ins

DB identifier Type Name
IPR017559 Family Alkyl hydroperoxide reductase subunit C
IPR013478 Family Methylamine dehydrogenase accessory protein MauD

3 GO Annotations

GO Term Gene Name
GO:0016209 IPR000866
GO:0016491 IPR000866
GO:0055114 IPR000866

3 Ontology Annotations

GO Term Gene Name
GO:0016209 IPR000866
GO:0016491 IPR000866
GO:0055114 IPR000866

1 Parent Features

DB identifier Type Name
IPR012336 Domain Thioredoxin-like fold

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
148807 D8RPL5 PAC:15410836 Selaginella moellendorffii 221  
148621 D8RNJ4 PAC:15409303 Selaginella moellendorffii 163  
28066 D8R098 PAC:15404783 Selaginella moellendorffii 161  
228619 D8S7N0 PAC:15409172 Selaginella moellendorffii 245  
234054 D8SHA0 PAC:15422414 Selaginella moellendorffii 179  
118659 D8SK77 PAC:15410134 Selaginella moellendorffii 149  
118949 D8SK76 PAC:15412415 Selaginella moellendorffii 172  
143457 D8R3X1 PAC:15415599 Selaginella moellendorffii 490  
140057 D8QNI9 PAC:15403627 Selaginella moellendorffii 168  
164163 D8QMW3 PAC:15408179 Selaginella moellendorffii 220  
36651 D8T2R1 PAC:15410841 Selaginella moellendorffii 114  
75178 D8QP17 PAC:15410624 Selaginella moellendorffii 171  
evm.TU.contig_32791.1 PAC:16430158 Carica papaya 106  
evm.model.supercontig_11.86 PAC:16405756 Carica papaya 322  
evm.model.supercontig_146.45 PAC:16409135 Carica papaya 222  
evm.model.supercontig_148.23 PAC:16409242 Carica papaya 233  
evm.model.supercontig_49.50 PAC:16421120 Carica papaya 245  
evm.model.supercontig_71.15 PAC:16425421 Carica papaya 167  
evm.model.supercontig_74.21 PAC:16425710 Carica papaya 238  
evm.model.supercontig_74.22 PAC:16425711 Carica papaya 170  
29848.m004526 B9RNU5 PAC:16811182 Ricinus communis 265  
29889.m003369 B9RZX8 PAC:16812315 Ricinus communis 219  
29912.m005490 B9RKM9 PAC:16813366 Ricinus communis 162  
30190.m011204 B9RCA6 PAC:16823561 Ricinus communis 168  
30190.m011205 B9RCA7 PAC:16823562 Ricinus communis 169  
31415.m000017 B9THV3 PAC:16825011 Ricinus communis 337  
34030.m000033 B9TFW1 PAC:16826070 Ricinus communis 388  
35014.m000021 B9TIG2 PAC:16826455 Ricinus communis 196  
43559.m000014 B9TPZ4 PAC:16827617 Ricinus communis 230  
47217.m000011 B9TKT9 PAC:16827972 Ricinus communis 92  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12517450