Protein Domain : IPR015797

Type:  Domain Name:  NUDIX hydrolase domain-like
Description:  MutT is a small bacterial protein (~12-15Kd) involved in the GO system [] responsible for removing an oxidatively damaged form of guanine (8-hydroxy-guanine or 7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with near equal efficiency, leading to A-T to G-C transversions. MutTspecifically degrades 8-oxo-dGTP to the monophosphate, with the concomitant release of pyrophosphate. A short conserved N-terminal region of mutT (designated the MutT domain) is also found in a variety of other prokaryotic, viral and eukaryotic proteins [, , , ].The generic name `NUDIX hydrolases' (NUcleoside DIphosphate linked to some other moiety X) has been coined for this domain family []. Thefamily can be divided into a number of subgroups, of which MutT anti- mutagenic activity represents only one type; most of the rest hydrolysediverse nucleoside diphosphate derivatives (including ADP-ribose, GDP- mannose, TDP-glucose, NADH, UDP-sugars, dNTP and NTP). Short Name:  NUDIX_hydrolase_dom-like
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2 Child Features

DB identifier Type Name
IPR000086 Domain NUDIX hydrolase domain
IPR029119 Domain MutY, C-terminal

4 Contains

DB identifier Type Name
IPR020476 Domain NUDIX hydrolase
IPR015376 Domain Zinc ribbon, NADH pyrophosphatase
IPR020084 Conserved_site NUDIX hydrolase, conserved site
IPR000059 Conserved_site NUDIX hydrolase, NudL, conserved site

2 Cross Referencess

Identifier
G3DSA:3.90.79.10
SSF55811

10 Found Ins

DB identifier Type Name
IPR003563 Family 7,8-dihydro-8-oxoguanine triphosphatase
IPR003293 Family Nudix hydrolase 6-like
IPR003561 Family Mutator MutT
IPR004385 Family Nucleoside diphosphate pyrophosphatase
IPR014078 Family Nucleoside triphosphatase YtkD
IPR003562 Family Mutator MutX protein
IPR003564 Family Dihydroneopterin triphosphate diphosphatase
IPR003565 Family Bis(5'-nucleosyl)-tetraphosphatase
IPR003300 Family Viral protein D9
IPR003301 Family Vaccinia virus D10, decapping enzyme

1 GO Annotation

GO Term Gene Name
GO:0016787 IPR015797

1 Ontology Annotations

GO Term Gene Name
GO:0016787 IPR015797

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
410858 D8RG35 PAC:15408719 Selaginella moellendorffii 221  
410980 D8RHM1 PAC:15409597 Selaginella moellendorffii 169  
5768 D8RKB0 PAC:15421022 Selaginella moellendorffii 128  
67467 D8QV61 PAC:15411528 Selaginella moellendorffii 175  
99897 D8RRE0 PAC:15419749 Selaginella moellendorffii 181  
150295 D8RVF9 PAC:15412576 Selaginella moellendorffii 259  
103175 D8RW55 PAC:15406770 Selaginella moellendorffii 202  
103171 D8RW71 PAC:15406765 Selaginella moellendorffii 240  
80228 D8QX43 PAC:15403710 Selaginella moellendorffii 198  
151789 D8S1P9 PAC:15419257 Selaginella moellendorffii 234  
176548 D8S3E0 PAC:15402001 Selaginella moellendorffii 355  
54771 D8S2U2 PAC:15420157 Selaginella moellendorffii 254  
438877 D8R034 PAC:15401957 Selaginella moellendorffii 325  
1746 D8S867 PAC:15409358 Selaginella moellendorffii 286  
85508 D8R632 PAC:15420652 Selaginella moellendorffii 165  
139849 D8QMV6 PAC:15406548 Selaginella moellendorffii 237  
85946 D8R5K2 PAC:15401455 Selaginella moellendorffii 291  
163872 D8QQL9 PAC:15410777 Selaginella moellendorffii 279  
429515 D8T6F4 PAC:15417587 Selaginella moellendorffii 241  
183198 D8SVX5 PAC:15419816 Selaginella moellendorffii 752  
73964 D8QNW5 PAC:15410860 Selaginella moellendorffii 180  
evm.model.supercontig_104.36 PAC:16405041 Carica papaya 242  
evm.model.supercontig_107.45 PAC:16405349 Carica papaya 206  
evm.model.supercontig_1105.3 PAC:16405823 Carica papaya 234  
evm.model.supercontig_116.67 PAC:16406326 Carica papaya 189  
evm.model.supercontig_12.144 PAC:16406686 Carica papaya 282  
evm.model.supercontig_132.5 PAC:16408146 Carica papaya 416  
evm.model.supercontig_136.34 PAC:16408324 Carica papaya 277  
evm.model.supercontig_2.207 PAC:16412572 Carica papaya 183  
evm.model.supercontig_2126.1 PAC:16413693 Carica papaya 226  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8810257
            1328155
            8226881
            8170394
            8233837
            10373642