Protein Domain : IPR001034

Type:  Domain Name:  DeoR-type HTH domain
Description:  The deoR-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 amino acids present in transcription regulators of the deoR family, involved in sugar catabolism. This family of prokaryotic regulators is named after the Escherichia coliprotein DeoR, a repressor of the deo operon, which encodes nucleotide and deoxyribonucleotide catabolic enzymes. DeoR also negatively regulates the expression of nupG and tsx, a nucleoside-specific transport protein and a channel-forming protein, respectively.DeoR-like transcription repressors occur in diverse bacteria as regulators of sugar and nucleoside metabolic systems. The effector molecules for deoR-likeregulators are generally phosphorylated intermediates of the relevant metabolic pathway. The DNA-binding deoR-type HTH domain occurs usually in theN-terminal part. The C-terminal part can contain an effector-binding domain and/or an oligomerisation domain. DeoR occurs as an octamer, whilst glpR andagaR are tetramers. Several operators may be bound simultaneously, which could facilitate DNA looping [, ].It is worth noting that the DeoR in this entry is represented by the protein, UniProt , from E. coli. Not the DeoR, UniProt , from Bacillus subtilis. Despite sharing the same name, these two proteins do not share protein sequence similarity []. Short Name:  DeoR_HTH
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0 Child Features

1 Contains

DB identifier Type Name
IPR018356 Conserved_site Transcription regulator, HTH DeoR-type, conserved site

4 Cross Referencess

Identifier
PF08220
PR00037
PS51000
SM00420

1 Found In

DB identifier Type Name
IPR016842 Family Protein of unknown function UCP026546, HtH-CBS

3 GO Annotations

GO Term Gene Name
GO:0003700 IPR001034
GO:0006355 IPR001034
GO:0005622 IPR001034

3 Ontology Annotations

GO Term Gene Name
GO:0003700 IPR001034
GO:0006355 IPR001034
GO:0005622 IPR001034

0 Parent Features

8 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Pp3s30_470V3.1.p PAC:32948496 Physcomitrium patens 2966  
Pp3s30_120V3.1.p PAC:32948460 Physcomitrium patens 326  
Pp3s30_940V3.1.p PAC:32948540 Physcomitrium patens 2687  
Pp3s34_504V3.1.p PAC:32948281 Physcomitrium patens 254  
Pp3s34_610V3.1.p PAC:32948312 Physcomitrium patens 2078  
Brdisv1pangenome1007746m.p PAC:33635731 Brachypodium distachyon Pangenome 868  
Brdisv1BdTR11A1042791m.p PAC:35691786 Brachypodium distachyon BdTR11a 868  
Brdisv1BdTR11A1041686m.p PAC:35693452 Brachypodium distachyon BdTR11a 974  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1731335
            14731281
            10714997