| Type: | Domain | Name: | Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain |
| Description: | This entry represents the catalytic domain of cobalamin-dependent enzymes, such as methylmalonyl-CoA mutase and glutamate mutase, which share a TIM beta/alpha-barrel structure. These enzymes are dependent upon cobalamin (vitamin B12) for activity [, ].Methylmalonyl-CoA mutase () (MCM) [] is an adenosylcobalamin (vitamin B12) dependent enzyme that catalyzes the isomerization between methylmalonyl-CoA and succinyl-CoA. MCM is involved in various catabolic or biosynthetic pathways; for example in man it is involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle; while in some bacteria it is involved in the synthesis of propionate from tricarboxylic acid-cycle intermediates.Glutamate mutase (methylaspartate mutase) catalyses the reversible interconversion of L-glutamate and L-threo-3-methylaspartate, the first step in the pathway of glutamate fermentation []. Catalysis is initiated using the cobalamin cofactor. | Short Name: | Cbl-dep_enz_cat-sub |
| DB identifier | Type | Name |
|---|---|---|
| IPR016176 | Domain | Cobalamin (vitamin B12)-dependent enzyme, catalytic |
| IPR006098 | Domain | Methylmalonyl-CoA mutase, alpha chain, catalytic |
| IPR006099 | Domain | Methylmalonyl-CoA mutase, alpha/beta chain, catalytic |
| IPR006396 | Family | Glutamate mutase epsilon subunit |
| IPR004608 | Family | Methylmalonyl-CoA mutase, beta chain |
| GO Term | Gene Name |
|---|---|
| GO:0016866 | IPR014348 |
| GO:0031419 | IPR014348 |
| GO:0008152 | IPR014348 |
