Protein Domain : IPR014033

Type:  Family Name:  Arginase
Description:  L-Arginine is converted to nitric oxide and citrulline by the enzyme nitric oxide synthase and by the enzyme arginase as a part of the hepatic urea cycle []. Arginase is a manganese metalloenzyme containing a metal-activated hydroxide ion, a critical nucleophile in metalloenzymes that catalyze hydrolysis or hydration reactions. A hydrogenbond formed by the metal-bound hydroxide holds the enzyme in the proper orientation for catalysis however non-metal substrate-binding sites are also implicated in the enzyme mechanism. Regeneration of metal-bound hydroxide ion from a metal-bound water molecule requires proton transfer to bulk solvent mediated by a histidine proton shuttle residue. Short Name:  Arginase
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0 Child Features

1 Contains

DB identifier Type Name
IPR020855 Binding_site Ureohydrolase, manganese-binding site

1 Cross References

Identifier
TIGR01229

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004053 IPR014033
GO:0046872 IPR014033
GO:0006525 IPR014033

3 Ontology Annotations

GO Term Gene Name
GO:0004053 IPR014033
GO:0046872 IPR014033
GO:0006525 IPR014033

1 Parent Features

DB identifier Type Name
IPR006035 Family Ureohydrolase

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Pahal.J00818.1 PAC:32488751 Panicum hallii 246  
Brdisv1pangenome1012026m.p PAC:33624009 Brachypodium distachyon Pangenome 295  
Brdisv1BdTR12c1039948m.p PAC:34404182 Brachypodium distachyon BdTR12c 295  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10931887