4 GO Annotations
| GO Term | Gene Name |
|---|---|
| GO:0004222 | IPR011546 |
| GO:0005524 | IPR011546 |
| GO:0008270 | IPR011546 |
| GO:0016021 | IPR011546 |
4 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0004222 | IPR011546 |
| GO:0005524 | IPR011546 |
| GO:0008270 | IPR011546 |
| GO:0016021 | IPR011546 |
| Type: | Domain | Name: | Peptidase M41, FtsH extracellular |
| Description: | Metalloproteases are the most diverse of the four main types of protease, with more than 50 families identified to date. In these enzymes, a divalent cation, usually zinc, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. The known metal ligands are His, Glu, Asp or Lys and at least one other residue is required for catalysis, which may play an electrophillic role. Of the known metalloproteases, around half contain an HEXXH motif, which has been shown in crystallographic studies to form part of the metal-binding site []. The HEXXH motif is relatively common, but can be more stringently defined for metalloproteases as 'abXHEbbHbc', where 'a' is most often valine or threonine and forms part of the S1' subsite in thermolysin and neprilysin, 'b' is an uncharged residue, and 'c' a hydrophobic residue. Proline is never found in this site, possibly because it would break the helical structure adopted bythis motif in metalloproteases [].This domain is found in the FtsH family of proteins that include FtsH a membrane-bound ATP-dependent protease universally conserved in prokaryotes []. The FtsH peptidases, which belong to MEROPS peptidase family M41 (clan MA(E)), efficiently degrade proteins that have a low thermodynamic stability - e.g. they lack robust unfoldase activity. This feature may be key and implies that this could be a criterion for degrading a protein. In Oenococcus oeni(Leuconostoc oenos) FtsH is involved in protection against environmental stress [], and shows increased expression under heat or osmotic stress. These two lines of evidence suggest that it is a fundamental prokaryotic self-protection mechanism that checks if proteins are correctly folded. The precise function of this N-terminal region is unclear. | Short Name: | Pept_M41_FtsH_extracell |
| GO Term | Gene Name |
|---|---|
| GO:0004222 | IPR011546 |
| GO:0005524 | IPR011546 |
| GO:0008270 | IPR011546 |
| GO:0016021 | IPR011546 |
| GO Term | Gene Name |
|---|---|
| GO:0004222 | IPR011546 |
| GO:0005524 | IPR011546 |
| GO:0008270 | IPR011546 |
| GO:0016021 | IPR011546 |
