Type: | Domain | Name: | Condensation domain |
Description: | This domain is found in many multi-domain enzymes which synthesize peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non-ribosomal peptide biosynthesis. It is usually found to the carboxyside of a phosphopantetheine binding domain (pp-binding). It has been shown that mutations in the HHXXXDG motif abolish activity suggesting this is part of the active site []. | Short Name: | Condensatn |