Protein Domain : IPR008047

Type:  Family Name:  Mini-chromosome maintenance complex protein 4
Description:  The MCM2-7 complex consists of six closely related proteins that are highly conserved throughout the eukaryotic kingdom. In eukaryotes, Mcm4 is a component of the MCM2-7 complex (MCM complex), which consists of six sequence-related AAA + type ATPases/helicases that form a hetero-hexameric ring []. MCM2-7 complex is part of the pre-replication complex (pre-RC). In G1 phase, inactive MCM2-7 complex is loaded onto origins of DNA replication [, , ]. During G1-S phase, MCM2-7 complex is activated to unwind the double stranded DNA and plays an important role in DNA replication forks elongation [].The components of the MCM2-7 complex are: . DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, DNA replication licensing factor MCM5, DNA replication licensing factor MCM6, DNA replication licensing factor MCM7, Mcm4 is thought to play a pivotal role in ensuring DNA replication occurs only once per cell cycle. Phosphorylation of Mcm4 dramatically reduces itsaffinity for chromatin - it has been proposed that this cell cycle-dependent phosphorylation is the mechanism that inactivates the MCM complex from lateS phase through mitosis, thus preventing illegitimate DNA replication during that period of the cell cycle []. Short Name:  MCM_4
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0 Child Features

2 Contains

DB identifier Type Name
IPR012340 Domain Nucleic acid-binding, OB-fold
IPR018525 Conserved_site Mini-chromosome maintenance, conserved site

1 Cross References

Identifier
PR01660

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0003677 IPR008047
GO:0003678 IPR008047
GO:0005524 IPR008047
GO:0006270 IPR008047
GO:0042555 IPR008047

5 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR008047
GO:0003678 IPR008047
GO:0005524 IPR008047
GO:0006270 IPR008047
GO:0042555 IPR008047

0 Parent Features

406 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
439569 D8R623 PAC:15402511 Selaginella moellendorffii 811  
evm.model.supercontig_150.47 PAC:16409502 Carica papaya 738  
evm.model.supercontig_30.68 PAC:16417019 Carica papaya 811  
30131.m007101 B9RHA7 PAC:16818924 Ricinus communis 867  
Cucsa.377820.1 A0A0A0K5P7 PAC:16982022 Cucumis sativus 844  
Cucsa.049050.1 PAC:16953977 Cucumis sativus 839  
Cucsa.049050.2 PAC:16953978 Cucumis sativus 835  
orange1.1g003637m A0A067EEX3 PAC:18100303 Citrus sinensis 806  
AT2G16440.1 Q0WVF5 PAC:19641260 Arabidopsis thaliana 847  
Thhalv10022552m V4M778 PAC:20202148 Eutrema salsugineum 837  
Ciclev10027842m V4SCX8 PAC:20814097 Citrus clementina 806  
Ciclev10027807m V4SI23 PAC:20814096 Citrus clementina 846  
Ciclev10019324m V4U147 PAC:20810238 Citrus clementina 619  
Lus10017491 PAC:23163201 Linum usitatissimum 822  
Lus10028795 PAC:23177301 Linum usitatissimum 838  
Potri.009G121500.2 PAC:26987792 Populus trichocarpa 821  
Potri.009G121500.1 A0A2K1Z6R5 PAC:26987791 Populus trichocarpa 827  
Potri.001G074000.1 PAC:27044223 Populus trichocarpa 834  
Gorai.013G033600.1 A0A0D2VA09 PAC:26788309 Gossypium raimondii 839  
Gorai.013G033600.2 A0A0D2W2G5 PAC:26788310 Gossypium raimondii 599  
Gorai.005G268500.1 A0A0D2Q091 PAC:26802417 Gossypium raimondii 727  
46876 I0Z1U4 PAC:27387191 Coccomyxa subellipsoidea C-169 783  
195678 PAC:27348707 Micromonas pusilla CCMP1545 972  
95766 C1EF87 PAC:27402506 Micromonas sp RCC299 817  
51954 A4SAW6 PAC:27420287 Ostreococcus lucimarinus 755  
Thecc1EG005965t8 A0A061DXK5 PAC:27460158 Theobroma cacao 625  
Thecc1EG005965t4 A0A061DWM3 PAC:27460156 Theobroma cacao 655  
Thecc1EG005965t6 A0A061DVJ0 PAC:27460157 Theobroma cacao 628  
Thecc1EG005965t7 A0A061DVS8 PAC:27460159 Theobroma cacao 570  
Thecc1EG005965t9 A0A061DWM8 PAC:27460160 Theobroma cacao 567  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            19896182
            19910535
            22841721
            17506634
            8901561