Protein Domain : IPR001054

Type:  Domain Name:  Adenylyl cyclase class-3/4/guanylyl cyclase
Description:  Guanylate cyclases () catalyse the formation of cyclic GMP (cGMP) from GTP. cGMP acts as an intracellular messenger, activating cGMP-dependent kinases and regulating cGMP-sensitive ion channels. The role of cGMP as a second messenger in vascular smooth muscle relaxation and retinal photo-transduction is well established. Guanylate cyclase is found both in the soluble and particulate fractions of eukaryotic cells. The soluble and plasmamembrane-bound forms differ in structure, regulation and other properties [, , , ]. Most currently known plasma membrane-bound forms are receptors for small polypeptides. The soluble forms of guanylate cyclase arecytoplasmic heterodimers having alpha and beta subunits.In all characterised eukaryote guanylyl- and adenylyl cyclases, cyclic nucleotide synthesis is carried out by the conserved class III cyclase domain. Short Name:  A/G_cyclase
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0 Child Features

1 Contains

DB identifier Type Name
IPR018297 Conserved_site Adenylyl cyclase class-4/guanylyl cyclase, conserved site

4 Cross Referencess

Identifier
PF00211
PS50125
SM00044
G3DSA:3.30.70.1230

1 Found In

DB identifier Type Name
IPR016577 Family Adenylate cylcase, type 10

3 GO Annotations

GO Term Gene Name
GO:0016849 IPR001054
GO:0009190 IPR001054
GO:0035556 IPR001054

3 Ontology Annotations

GO Term Gene Name
GO:0016849 IPR001054
GO:0009190 IPR001054
GO:0035556 IPR001054

1 Parent Features

DB identifier Type Name
IPR029787 Domain Nucleotide cyclase

725 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
84652 D8R3A4 PAC:15418623 Selaginella moellendorffii 258  
427736 D8T0K1 PAC:15413356 Selaginella moellendorffii 1167  
30192.m000546 B9S0P3 PAC:16823711 Ricinus communis 117  
31129.m000022 B9TGN5 PAC:16824828 Ricinus communis 114  
27669.m000057 B9T8Z8 PAC:16798930 Ricinus communis 777  
AT1G58360.1 Q42400 PAC:19650605 Arabidopsis thaliana 485  
Thhalv10009701m V4L7V9 PAC:20186868 Eutrema salsugineum 469  
Potri.003G131800.2 PAC:26998525 Populus trichocarpa 322  
Potri.003G131800.1 PAC:26998524 Populus trichocarpa 366  
14531 I0Z231 PAC:27387571 Coccomyxa subellipsoidea C-169 800  
58306 I0YMD9 PAC:27394449 Coccomyxa subellipsoidea C-169 829  
56833 I0YTB1 PAC:27391587 Coccomyxa subellipsoidea C-169 2769  
67530 I0YP82 PAC:27393985 Coccomyxa subellipsoidea C-169 1730  
59862 C1MYC6 PAC:27338775 Micromonas pusilla CCMP1545 752  
51048 C1N0J9 PAC:27340530 Micromonas pusilla CCMP1545 1033  
52807 C1N558 PAC:27339960 Micromonas pusilla CCMP1545 590  
15376 C1MM72 PAC:27347767 Micromonas pusilla CCMP1545 344  
49967 C1MGW9 PAC:27345018 Micromonas pusilla CCMP1545 919  
62793 PAC:27405267 Micromonas sp RCC299 779  
62949 C1FJL1 PAC:27399898 Micromonas sp RCC299 890  
55932 C1DYI2 PAC:27396908 Micromonas sp RCC299 1718  
31861 A4RXY6 PAC:27416837 Ostreococcus lucimarinus 906  
93452 A4S4Q7 PAC:27420463 Ostreococcus lucimarinus 309  
40949 A4RY97 PAC:27418509 Ostreococcus lucimarinus 214  
33636 A4S310 PAC:27413858 Ostreococcus lucimarinus 646  
Araha.5132s0001.1.p PAC:28854295 Arabidopsis halleri 485  
Cagra.3356s0011.1.p PAC:28898139 Capsella grandiflora 527  
Cagra.3674s0001.2.p PAC:28894694 Capsella grandiflora 371  
Cagra.3674s0001.1.p PAC:28894693 Capsella grandiflora 464  
Cagra.4395s0190.1.p PAC:28898468 Capsella grandiflora 475  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1349465
            1356629
            1680765
            1982420