Protein Domain : IPR001194

Type:  Domain Name:  DENN domain
Description:  The tripartite DENN (after differentially expressed in neoplastic versus normal cells) domain is found in several proteins involved in Rab-mediatedprocesses or regulation of MAPKs (Mitogen-activated preotein kinases) signaling pathways. It actually consists of three parts as the original DENNdomain is always encircled on both sides by more divergent domains, called uDENN (after upstream DENN) and dDENN (for downstream DENN). The tripartiteDENN domain is found associated with other domains, such as RUN, PLAT, PH, PPR, WD-40, GRAM or C1. The function of DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity [, ].The general characteristics of DENN domains - three regions dDENN, DENN itself, and uDENN having different patterns of sequence conservation andseparated by sequences of variable length - suggest that they are composed of at least three sub-domains which may feature distinct folds but which arealways associated due to functional and/or structural constraints [].Some proteins known to contain a tripartite DENN domain are listed below:Rat Rab3 GDP/GTP exchange protein (Rab3GEP) Human mitogen-activated protein kinase activating protein containing death domain (MADD). It is orthologous to Rab3GEP Caenorhabditis elegans regulator of presynaptic activity aex-3, the ortholog of Rab3GEP Mouse Rab6 interacting protein 1 (Rab6IP1) Human SET domain-binding factor 1(SBF1) Human suppressor of tumoreginicity 5 (ST5) Human C-MYC promoter-binding protein IRLB This entry represents the DENN domain. Short Name:  DENN_dom

0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF02141
PS50211
SM00799

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
118822 D8SKF3 PAC:15411603 Selaginella moellendorffii 1180  
445651 D8SK60 PAC:15421054 Selaginella moellendorffii 801  
evm.TU.contig_35789.1 PAC:16430715 Carica papaya 404  
evm.model.supercontig_13.14 PAC:16407647 Carica papaya 872  
29739.m003773 B9RRB9 PAC:16807550 Ricinus communis 730  
30174.m008710 B9RE28 PAC:16822356 Ricinus communis 1204  
29637.m000724 B9SKL1 PAC:16804375 Ricinus communis 765  
Cucsa.113710.2 PAC:16960366 Cucumis sativus 1179  
Cucsa.113710.1 A0A0A0LTM5 PAC:16960365 Cucumis sativus 1209  
Cucsa.117310.1 A0A0A0LIL0 PAC:16960719 Cucumis sativus 798  
Cucsa.117310.3 PAC:16960721 Cucumis sativus 778  
Cucsa.117310.4 PAC:16960722 Cucumis sativus 771  
Cucsa.117310.2 A0A0A0LIL0 PAC:16960720 Cucumis sativus 798  
Cucsa.348800.2 PAC:16979662 Cucumis sativus 523  
Cucsa.348800.1 PAC:16979661 Cucumis sativus 819  
orange1.1g001042m PAC:18119259 Citrus sinensis 1178  
orange1.1g001039m PAC:18119258 Citrus sinensis 1179  
orange1.1g039032m A0A067FA32 PAC:18113820 Citrus sinensis 520  
orange1.1g003143m A0A067EEI9 PAC:18123726 Citrus sinensis 844  
orange1.1g003734m A0A067EHX9 PAC:18123727 Citrus sinensis 799  
orange1.1g005821m A0A067EQM2 PAC:18123730 Citrus sinensis 676  
orange1.1g003733m A0A067EHX9 PAC:18123728 Citrus sinensis 799  
orange1.1g007859m A0A067EEJ3 PAC:18123731 Citrus sinensis 587  
orange1.1g004201m A0A067ERG4 PAC:18123729 Citrus sinensis 768  
AT5G35560.1 F4JZV9 PAC:19667663 Arabidopsis thaliana 765  
AT1G49040.3 F4I061 PAC:19655536 Arabidopsis thaliana 1040  
AT1G49040.1 Q8RXA7 PAC:19655535 Arabidopsis thaliana 1187  
AT1G49040.2 F4I062 PAC:19655537 Arabidopsis thaliana 909  
AT2G20320.1 F4IUH2 PAC:19638452 Arabidopsis thaliana 1029  
Thhalv10001892m V4M5X1 PAC:20200704 Eutrema salsugineum 1023  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11563850
            12906859