Protein Domain : IPR012338

Type:  Domain Name:  Beta-lactamase/transpeptidase-like
Description:  This entry represents a beta-lactamase structural motif, which contains a cluster of alpha-helices and an alpha/beta sandwich. In addition to beta-lactamases, this domain is also found in D-ala carboxypeptidase/transpeptidase, esterase (EstB) [], the penicillin receptor BlaR (C-terminal domain), D-aminopeptidase (N-terminal domain) [], penicillin-biding proteins (e.g. PBP2x, PBP5), and in glutaminase (GlnA). Beta-lactamases are the most common bacterial resistance mechanism against beta-lactam antibiotics []. Beta-lactamases appear to have evolved from DD-transpeptidases, which are penicillin-binding proteins involved in cell wall biosynthesis, and as such are one of the main targets of beta-lactam antibiotics. Short Name:  Beta-lactam/transpept-like
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3 Child Features

DB identifier Type Name
IPR001466 Domain Beta-lactamase-related
IPR001460 Domain Penicillin-binding protein, transpeptidase
IPR001967 Domain Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal

2 Contains

DB identifier Type Name
IPR002137 Active_site Beta-lactamase, class-D active site
IPR001586 Active_site Beta-lactamase, class-C active site

2 Cross Referencess

Identifier
G3DSA:3.40.710.10
SSF56601

4 Found Ins

DB identifier Type Name
IPR000667 Family Peptidase S13, D-Ala-D-Ala carboxypeptidase C
IPR000871 Family Beta-lactamase, class-A
IPR018044 Family Peptidase S11, D-alanyl-D-alanine carboxypeptidase A
IPR015868 Family Glutaminase

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
266894 D8R150 PAC:15411547 Selaginella moellendorffii 891  
85583 D8R6S4 PAC:15420838 Selaginella moellendorffii 918  
evm.TU.contig_36670.1 PAC:16430895 Carica papaya 78  
evm.TU.contig_43863.1 PAC:16431930 Carica papaya 94  
evm.model.supercontig_142.37 PAC:16408966 Carica papaya 272  
evm.model.supercontig_328.6 PAC:16417532 Carica papaya 965  
evm.model.supercontig_43.79 PAC:16420040 Carica papaya 103  
evm.model.supercontig_48.215 PAC:16420857 Carica papaya 150  
30836.m000014 B9TIH0 PAC:16824648 Ricinus communis 408  
31359.m000016 B9TGS8 PAC:16824974 Ricinus communis 369  
34359.m000017 B9TEE0 PAC:16826191 Ricinus communis 458  
35543.m000026 B9TF38 PAC:16826662 Ricinus communis 276  
51747.m000013 B9TP52 PAC:16828449 Ricinus communis 277  
52783.m000022 PAC:16828559 Ricinus communis 120  
52054.m000014 B9TH63 PAC:16828482 Ricinus communis 302  
53473.m000023 B9TI31 PAC:16828618 Ricinus communis 269  
56977.m000013 B9TKN7 PAC:16829003 Ricinus communis 343  
59781.m000014 PAC:16829287 Ricinus communis 255  
28064.m000042 B9T9A0 PAC:16799843 Ricinus communis 710  
27438.m000028 B9TCA2 PAC:16798320 Ricinus communis 209  
27438.m000029 B9TCA3 PAC:16798321 Ricinus communis 411  
28226.m000855 B9SPR5 PAC:16800390 Ricinus communis 965  
27580.m000026 B9TB72 PAC:16798751 Ricinus communis 465  
27472.m000313 B9T7I5 PAC:16798463 Ricinus communis 606  
Cucsa.135930.1 PAC:16963016 Cucumis sativus 475  
Cucsa.311260.1 PAC:16976654 Cucumis sativus 965  
orange1.1g043763m A0A067DFS9 PAC:18137878 Citrus sinensis 70  
orange1.1g005658m A0A067FUW9 PAC:18109009 Citrus sinensis 685  
orange1.1g006444m A0A067FIK2 PAC:18109011 Citrus sinensis 645  
orange1.1g005995m A0A067FVK6 PAC:18109010 Citrus sinensis 666  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10986464
            12945052
            11847270