| Type: | Domain | Name: | Membrane associated eicosanoid/glutathione metabolism-like domain |
| Description: | This domain is found in a widespread superfamily known as MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) []. Included in this superfamily are:5-lipoxygenase activating protein (gene FLAP), which seems to be required for the activation of 5-lipoxygenase.Leukotriene C4 synthase (), which catalyses the production of LTC4 from LTA4.Microsomal glutathione S-transferase II () (GST-II), which also produces LTC4 from LTA4.Prostaglandin E synthase, which catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). The domain consists of four transmembrane helices []. | Short Name: | MAPEG-like_dom |
