Protein Domain : IPR005677

Type:  Family Name:  Fumarate hydratase, class II
Description:  Fumarate hydratase class II (also known as Fumarase C) catalyses the stereospecific interconversion of fumarate to L-malate as part of the metabolic citric acid or Kreb's cycle. The recent three-dimensional structure of fumarase C from Escherichia colihas identified a binding site for anions which is generated by side chains from three of the four subunits within the tetramer. These same side chains are found in the three most highly conserved regions within the class II fumarate hydratase family. Putative fumarases from several species (Mycobacterium tuberculosis, Streptomyces coelicolor, Pseudomonas aeruginosa) branch deeply, although within the same branch of a phylogenetic tree rooted by aspartate ammonia-lyase sequences. Short Name:  Fum_hydII
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0 Child Features

3 Contains

DB identifier Type Name
IPR018951 Domain Fumarase C, C-terminal
IPR022761 Domain Fumarate lyase, N-terminal
IPR020557 Conserved_site Fumarate lyase, conserved site

2 Cross Referencess

Identifier
TIGR00979
MF_00743

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004333 IPR005677
GO:0006106 IPR005677
GO:0045239 IPR005677

3 Ontology Annotations

GO Term Gene Name
GO:0004333 IPR005677
GO:0006106 IPR005677
GO:0045239 IPR005677

1 Parent Features

DB identifier Type Name
IPR000362 Family Fumarate lyase family

430 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
113300 D8SC31 PAC:15415473 Selaginella moellendorffii 621  
evm.model.supercontig_151.34 PAC:16409552 Carica papaya 492  
29986.m001664 B9SAW4 PAC:16815162 Ricinus communis 470  
Cucsa.096910.1 A0A0A0KWM0 PAC:16958113 Cucumis sativus 495  
Cucsa.096910.2 PAC:16958114 Cucumis sativus 404  
orange1.1g014519m A0A067H537 PAC:18136856 Citrus sinensis 423  
orange1.1g015619m A0A067H5H8 PAC:18136858 Citrus sinensis 403  
orange1.1g014483m A0A067H537 PAC:18136857 Citrus sinensis 423  
orange1.1g010908m A0A067HGD8 PAC:18136851 Citrus sinensis 497  
orange1.1g010951m A0A067HGD8 PAC:18136852 Citrus sinensis 497  
orange1.1g011379m A0A067H5H3 PAC:18136853 Citrus sinensis 487  
AT5G50950.2 Q9FI53 PAC:19667461 Arabidopsis thaliana 499  
AT5G50950.1 B9DFR5 PAC:19667460 Arabidopsis thaliana 510  
AT5G50950.3 PAC:19667462 Arabidopsis thaliana 423  
AT2G47510.1 P93033 PAC:19640939 Arabidopsis thaliana 492  
AT2G47510.2 P93033 PAC:19640940 Arabidopsis thaliana 492  
Thhalv10001422m V4L6T9 PAC:20189224 Eutrema salsugineum 492  
Ciclev10019851m V4TVX9 PAC:20807610 Citrus clementina 494  
Ciclev10019838m V4VWH7 PAC:20807609 Citrus clementina 497  
Ciclev10019839m V4VWH7 PAC:20807608 Citrus clementina 497  
Lus10009114 PAC:23150029 Linum usitatissimum 500  
Lus10032296 PAC:23168592 Linum usitatissimum 536  
Lus10028532 PAC:23166112 Linum usitatissimum 505  
Potri.002G201300.1 B9GSD7 PAC:27021000 Populus trichocarpa 490  
Potri.002G201300.2 PAC:27021001 Populus trichocarpa 462  
Potri.002G201300.4 PAC:27021003 Populus trichocarpa 423  
Gorai.001G141300.1 A0A0D2LYP1 PAC:26823695 Gossypium raimondii 496  
Gorai.001G141300.2 A0A0D2LYP1 PAC:26823696 Gossypium raimondii 496  
12444 I0Z6W7 PAC:27393255 Coccomyxa subellipsoidea C-169 489  
149445 C1MI52 PAC:27345999 Micromonas pusilla CCMP1545 461  

0 Publications