3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0004163 | IPR029765 |
| GO:0019287 | IPR029765 |
| GO:0005829 | IPR029765 |
1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR005935 | Family | Diphosphomevalonate/phosphomevalonate decarboxylase |
| Type: | Family | Name: | Diphosphomevalonate decarboxylase |
| Description: | This group of enzymes belongs to the GHMP kinase domain superfamily. GHMP kinases are a unique class of ATP-dependent enzymes (the abbreviation of which refers to the original members: galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase) []. Enzymes belonging to this superfamily contain three well-conserved motifs, the second of which has the typical sequence Pro-X-X-X-Gly-Leu-X-Ser-Ser-Ala and is involved in ATP binding []. The phosphate binding loop in GHMP kinases is distinct from the classical P-loops found in many ATP/GTP binding proteins. The bound ADP molecule adopts a rare syn conformation and is in the opposite orientation from those bound to the P-loop-containing proteins []. GHMP kinases display a distinctly bilobal appearance with their N-terminal subdomains dominated by a mixed beta-sheet flanked on one side by alpha-helices and their C-terminal subdomains containing a four stranded anti-parallel beta-sheet [, , , ]. Diphosphomevalonate decarboxylase (mevalonate pyrophosphate decarboxylase, () catalyzes the decarboxylation of mevalonate pyrophosphate to isopentyl pyrophosphate (IPP) [], the last step in the synthesis of IPP in the mevalonate pathway. In archaea, an alternate pathway involves decarboxylation of mevalonate monophosphate instead of diphosphomevalonate []. Mevalonate is a key intermediate in the biosynthesis of sterols and non-sterol isoprenes in the mevalonate pathway. In mammals, the majority of mevalonate is converted into cholesterol.ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2 | Short Name: | Mev_diP_decarb |
| GO Term | Gene Name |
|---|---|
| GO:0004163 | IPR029765 |
| GO:0019287 | IPR029765 |
| GO:0005829 | IPR029765 |
| DB identifier | Type | Name |
|---|---|---|
| IPR005935 | Family | Diphosphomevalonate/phosphomevalonate decarboxylase |
