Protein Domain : IPR027439

Type:  Domain Name:  Protective antigen, heptamerisation domain
Description:  Protective antigen (PA) is the central component of the three-part protein toxin secreted by Bacillus anthracis, the organism responsible for anthrax. Homologues of PA have been found in several spore-forming Gram-positive bacteria, and share the ability to translocate toxic enzymes into the host cytosol.The PA monomer is organised mainly into antiparallel beta-sheets and has four domains: an N-terminal domain (domain 1) containing two calcium ions and the cleavage site for activating proteases; a heptamerisation domain (domain 2) containing a large flexible loop implicated in membrane insertion; a small domain of unknown function (domain 3); and a carboxy-terminal receptor-binding domain (domain 4) []. This entry represents domain 2 of PA. Short Name:  PA_heptamer_dom
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0 Child Features

0 Contains

1 Cross References

Identifier
G3DSA:2.60.120.240

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0051260 IPR027439

1 Ontology Annotations

GO Term Gene Name
GO:0051260 IPR027439

0 Parent Features

167 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cucsa.360700.2 PAC:16980789 Cucumis sativus 675  
Cucsa.360700.3 PAC:16980790 Cucumis sativus 631  
Cucsa.360700.1 PAC:16980788 Cucumis sativus 863  
Lus10010312 PAC:23169514 Linum usitatissimum 196  
59877 C1MYD9 PAC:27339039 Micromonas pusilla CCMP1545 683  
104615 C1EJ89 PAC:27397163 Micromonas sp RCC299 427  
Araha.1283s0001.1.p PAC:28841254 Arabidopsis halleri 302  
Cagra.0043s0015.1.p PAC:28899259 Capsella grandiflora 142  
Brara.D01748.1.p A0A397ZMC8 PAC:30621014 Brassica rapa FPsc 111  
Brara.I00855.1.p A0A397XS11 PAC:30641545 Brassica rapa FPsc 303  
Bostr.5325s0010.1.p PAC:30675187 Boechera stricta 361  
Bradi1g28570.2.p PAC:31136674 Brachypodium distachyon 246  
Medtr1g067410.1 I3SNE9 PAC:31100655 Medicago truncatula 331  
Medtr6g053360.1 A0A072UKP7 PAC:31101373 Medicago truncatula 86  
SapurV1A.0420s0150.1.p PAC:31431008 Salix purpurea 561  
Kalax.0040s0050.2.p PAC:32595397 Kalanchoe laxiflora 287  
Bradi1g28571.1.p A0A0Q3GZY2 PAC:32799924 Brachypodium distachyon 384  
Bradi3g50886.2.p A0A0Q3M8C8 PAC:32822107 Brachypodium distachyon 265  
Bradi3g50886.1.p A0A0Q3M8C8 PAC:32822106 Brachypodium distachyon 265  
LOC_Os03g60660.1 PAC:33128851 Oryza sativa 228  
Zosma9971g00010.1 A0A0K9NHT0 PAC:33173638 Zostera marina 72  
Brdisv1Per11024204m.p A0A0Q3GZY2 PAC:33205906 Brachypodium distachyon Per1 384  
Brdisv1Uni21029603m.p A0A0Q3GZY2 PAC:33286320 Brachypodium distachyon Uni2 384  
Brdisv1Bd3-1_r1018776m.p PAC:33303448 Brachypodium distachyon Bd3-1 353  
Brdisv1BdTR7a1004756m.p PAC:33345420 Brachypodium distachyon BdTR7a 246  
Brdisv1Koz-11031663m.p PAC:33415807 Brachypodium distachyon Koz-1 221  
Brdisv1Koz-11038915m.p A0A0Q3M8C8 PAC:33419757 Brachypodium distachyon Koz-1 265  
Brdisv1Koz-11038916m.p A0A0Q3M8C8 PAC:33419756 Brachypodium distachyon Koz-1 265  
Brdisv20Bd21Ref1033807m.p A0A0Q3M8C8 PAC:33467560 Brachypodium distachyon Bd21 AnntCtrl 265  
Brdisv20Bd21Ref1033806m.p A0A0Q3M8C8 PAC:33467561 Brachypodium distachyon Bd21 AnntCtrl 265  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9039918