1 Contains
| DB identifier | Type | Name |
|---|---|---|
| IPR006186 | Domain | Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase |
| Type: | Family | Name: | Phosphoprotein phosphatase PPZ/Ppq1 |
| Description: | This group represents the yeast phosphoprotein phosphatase, Ppz-type. Ppz proteins function in the regulation of K+ transport. Ppz proteins and the Hal3p inhibitory subunit of Ppz1 are important determinants of salt tolerance, cell wall integrity and cell cycle progression, each of which is dependent upon the Trk K+ transporters [, ]. The decreased Ppz activity found in Ppz mutants results in the activation of Trk and the subsequent plasma membrane depolarisation (reducing uptake of toxic cations), increased intracellular K+ and turgor (compromising cell integrity), and increased intracellular pH (augmenting the expression of pH-regulated genes and facilitating alpha-factor recovery). Ppz1 orthologues are found only in fungi [].Ppq1 yeast phosphatase consists of two distinct domains: the C-terminal phosphatase domain is approximately 60% identical to either PP1 or the carboxy-terminal domains of PPZ1 and PPZ2, while the N-terminal region is rich in serine and asparagine. Ppq1 seems to be involved in the regulation of protein synthesis [] and functions as a negative regulator of the mating MAPK pathway []. | Short Name: | PPPtase_PPZ/Ppq1 |
| DB identifier | Type | Name |
|---|---|---|
| IPR006186 | Domain | Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase |
