| Type: | Family | Name: | Histone-lysine N-methyltransferase Smyd3 |
| Description: | This family of enzymes specifically methylate 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It plays an important role in transcriptional activation as a member of an RNA polymerase complex. It also binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences [].Methyltransferases (EC 2.1.1.-) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [, , ]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM []. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [, , ]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [, , ]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor. | Short Name: | Hist-Lys_N-MeTrfase_Smyd3 |
